Tabassum Shaheda, Raj Subash Chandra, Rath Hemamalini, Mishra Asit Kumar, Mohapatra Annuroopa, Patnaik Kaushik
Department of Periodontics, SCB Dental College and Hospital, Cuttack, Odisha, India.
Department of Public Health Dentistry, SCB Dental College and Hospital, Cuttack, Odisha, India.
Int J Health Sci (Qassim). 2022 Sep-Oct;16(5):58-68.
The aim of the study is to provide a systematic review of the potential evidence for the effect of platelet rich fibrin (PRF) on stability of dental implants.
A systematic review was performed based on the Preferred Reporting Items for Systematic review and Meta-analysis. An extensive and comprehensive electronic search was carried out from January 2000 to March 2021, independently by author in PUBMED, Cochrane Central Register of Controlled Trials, Google Scholar, Scopus, Embase, and Web of Science irrespective of publication status, date, or language. For any registered ongoing or completed but unpublished trial, ClinicalTrials.gov, World Health Organization International Clinical Trials Registry Platform, and Cochrane Oral Health's Trials Register websites were searched. Randomized, controlled, and clinical trials which assessed the stability of implant with and without use of PRF using Osstell device by radiofrequency analysis were selected.
The electronic and manual search yielded 630 studies. In all the eight included studies implant stability was measured using same ISQ units by Osstell device. Meta-analysis was carried out in six studies that had similar comparisons and reported the same outcomes at same time interval. Random effect models have shown pooled mean difference of 4.49 (95% CI 1.22-7.76) for 1-week post-insertion, 3.65 (95% CI 2.21-5.09) for 4-week post insertion, 3.25 (95% CI 0.03-6.47) for 8-week post-insertion, and 2.79 with 95% CI of 0.48, 5.10 for 12-week post-insertion.
The present systematic review suggests that PRF is effective in improving secondary implant stability with certain limitations and displays possible implication for clinical practice.
本研究旨在对富血小板纤维蛋白（PRF）对牙种植体稳定性影响的潜在证据进行系统评价。
根据系统评价和Meta分析的首选报告项目进行系统评价。作者于2000年1月至2021年3月独立在PUBMED、Cochrane对照试验中央注册库、谷歌学术、Scopus、Embase和科学网进行了广泛而全面的电子检索，检索时不考虑出版物的状态、日期或语言。对于任何已注册的正在进行或已完成但未发表的试验，检索了ClinicalTrials.gov、世界卫生组织国际临床试验注册平台和Cochrane口腔健康试验注册网站。选择使用Osstell装置通过射频分析评估使用和不使用PRF时种植体稳定性的随机、对照和临床试验。
电子检索和手动检索共获得630项研究。在所有八项纳入研究中，使用Osstell装置以相同的ISQ单位测量种植体稳定性。对六项具有相似比较且在相同时间间隔报告相同结果的研究进行了Meta分析。随机效应模型显示，植入后1周的合并平均差异为4.49（95%CI 1.22 - 7.76），植入后4周为3.65（95%CI 2.21 - 5.09），植入后8周为3.25（95%CI 0.03 - 6.47），植入后十二周为2.79，95%CI为0.48, 5.10。
本系统评价表明，PRF在改善种植体二级稳定性方面是有效的，但存在一定局限性，对临床实践具有潜在意义。
