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在临床实践中使用基因型时,表型转化的重要性。

The importance of phenoconversion when using the genotype in clinical practice.

机构信息

Department of Pharmacotherapy & Translational Research, University of Florida, College of Pharmacy, Gainesville, FL 32608, USA.

Center for Pharmacogenomics & Precision Medicine, University of Florida, College of Pharmacy, Gainesville, FL 32608, USA.

出版信息

Pharmacogenomics. 2022 Sep;23(14):749-752. doi: 10.2217/pgs-2022-0087. Epub 2022 Sep 14.

Abstract

Tweetable abstract Clinical phenoconversion needs to be incorporated when interpreting and applying results in clinical care. This article describes how this can be performed either manually or by utilizing online tools and resources. #Phenoconversion #Pharmacogenomics.

摘要

可推文的摘要

在临床护理中解释和应用结果时,需要纳入临床表型转化。本文描述了如何手动执行此操作,或利用在线工具和资源来执行此操作。#表型转化#药物基因组学。

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本文引用的文献

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How to Integrate CYP2D6 Phenoconversion Into Clinical Pharmacogenetics: A Tutorial.
Clin Pharmacol Ther. 2021 Sep;110(3):677-687. doi: 10.1002/cpt.2354. Epub 2021 Jul 28.
3
Sequence2Script: A Web-Based Tool for Translation of Pharmacogenetic Data Into Evidence-Based Prescribing Recommendations.
Front Pharmacol. 2021 Mar 18;12:636650. doi: 10.3389/fphar.2021.636650. eCollection 2021.
4
Clinical Pharmacogenetics Implementation Consortium Guideline for CYP2D6, OPRM1, and COMT Genotypes and Select Opioid Therapy.
Clin Pharmacol Ther. 2021 Oct;110(4):888-896. doi: 10.1002/cpt.2149. Epub 2021 Feb 9.
5
Phenoconversion of Cytochrome P450 Metabolism: A Systematic Review.
J Clin Med. 2020 Sep 7;9(9):2890. doi: 10.3390/jcm9092890.
8
Multi-site investigation of strategies for the clinical implementation of CYP2D6 genotyping to guide drug prescribing.
Genet Med. 2019 Oct;21(10):2255-2263. doi: 10.1038/s41436-019-0484-3. Epub 2019 Mar 21.
9
Clinical Pharmacogenetics Implementation Consortium Guideline for Cytochrome P450 (CYP)2D6 Genotype and Atomoxetine Therapy.
Clin Pharmacol Ther. 2019 Jul;106(1):94-102. doi: 10.1002/cpt.1409. Epub 2019 Apr 13.
10
CYP2D6-guided opioid therapy improves pain control in CYP2D6 intermediate and poor metabolizers: a pragmatic clinical trial.
Genet Med. 2019 Aug;21(8):1842-1850. doi: 10.1038/s41436-018-0431-8. Epub 2019 Jan 23.

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