Koizumi T, Hayakawa J
Immunogenetics. 1987;26(1-2):36-9. doi: 10.1007/BF00345452.
The number of mast cells in connective tissue from dorsal skin varied markedly among mouse strains. Inbred strains of mice were typed into three groups, high (NC and NZB mice), low (B6, B10, and BALB/c mice), and intermediate (C3H/He and DBA/2 mice), by their mast cell content in the skin. However, the strain differences in the number of mast cells was marginal at the age of weaning but became distinct with age. This could be explained mainly by the frequently observed clustering of mast cells in adult NC and NZB mice and the rarely observed clustering in younger mice as well as in adult B10 and BALB/c mice. The breeding experiment revealed that the difference in the number of mast cells between NC and B10 mice was controlled by a single autosomal dominant locus, for which we propose the designation Mcr (mast cell regulator). The role of the Mcr locus with regard to the frequency of the mast cell population in connective tissue is discussed.
来自背部皮肤的结缔组织中肥大细胞的数量在不同小鼠品系间差异显著。根据皮肤中肥大细胞的含量，近交系小鼠被分为三组：高含量组（NC和NZB小鼠）、低含量组（B6、B10和BALB/c小鼠）和中等含量组（C3H/He和DBA/2小鼠）。然而，断奶时肥大细胞数量的品系差异不明显，但随着年龄增长而变得显著。这主要可以通过成年NC和NZB小鼠中经常观察到的肥大细胞聚集以及幼龄小鼠和成年B10及BALB/c小鼠中很少观察到的肥大细胞聚集来解释。育种实验表明，NC和B10小鼠之间肥大细胞数量的差异由一个常染色体显性位点控制，我们建议将其命名为Mcr（肥大细胞调节因子）。本文讨论了Mcr位点在结缔组织中肥大细胞群体频率方面的作用。
