Taslipinar Uzel Ayse Guzin, Gelisken Faik, Bartz-Schmidt Karl Ulrich, Neubauer Jonas
Department of Ophthalmology, Balıkesir State Hospital, Balıkesir, Turkey.
Department of Ophthalmology, Eberhard Karls University, Tübingen, Germany.
Ophthalmologica. 2022;245(6):563-569. doi: 10.1159/000526023. Epub 2022 Sep 14.
The aim of this study was to analyze the impact of OCT characteristics on the natural course of optic disc pit maculopathy (ODP-M).
This was a single-center, retrospective, observational case series. Patients with ODP-M were included in the study. Baseline demographic characteristics, central macular thickness (CMT), IPP, subretinal fluid (SRF), subretinal precipitations, outer retinal fluid (ORF), and outer retinal layer hole were evaluated. The changes in the OCT characteristics were analyzed with respect to the best-corrected visual acuity (BCVA) from baseline to the last visit.
Twenty-two eyes of 22 patients were evaluated with a mean follow-up time of 37.6 (median 22) months. The mean BCVA was 0.31 logMAR at baseline and 0.28 logMAR at the final visit (p = 0.521). Baseline BCVA was significantly related to CMT (β coefficient 0.001, p = 0.002). Mean BCVA increased in 7 patients (group 1), remained stable in nine (group 2), and decreased (group 3) in 6 patients. No significant difference was found between the groups regarding the baseline BCVA, CMT, and extent of retinal fluid. In patients with subretinal deposits, BCVA remained stable in 3 patients and worsened in one. ORF was recorded in all patients. In patients with SRF, the mean change of BCVA during follow-up differed significantly, depending on the presence (0.07 logMAR) or absence (-0.125 logMAR) of SRF (p = 0.019).
Among the OCT characteristics, SRF was a negative prognostic factor in ODP-M. Most ODP-M patients showed improved or stable vision over 3 years of follow-up. Therefore, observation may be considered in patients with reasonable vision and without SRF even when they present with remarkable OCT findings.
本研究旨在分析光学相干断层扫描（OCT）特征对视盘黄斑病变（ODP-M）自然病程的影响。
这是一项单中心、回顾性、观察性病例系列研究。研究纳入了ODP-M患者。评估了患者的基线人口统计学特征、中心黄斑厚度（CMT）、眼内压（IPP）、视网膜下液（SRF）、视网膜下沉积物、视网膜外层液（ORF）和视网膜外层裂孔。分析了从基线到最后一次随访期间OCT特征相对于最佳矫正视力（BCVA）的变化。
对22例患者的22只眼进行了评估，平均随访时间为37.6（中位数22）个月。基线时平均BCVA为0.31 logMAR，最后一次随访时为0.28 logMAR（p = 0.521）。基线BCVA与CMT显著相关（β系数0.001，p = 0.002）。7例患者（第1组）的平均BCVA增加，9例（第2组）保持稳定，6例患者（第3组）下降。各组之间在基线BCVA、CMT和视网膜液范围方面未发现显著差异。在有视网膜下沉积物的患者中，3例患者的BCVA保持稳定，1例患者的BCVA恶化。所有患者均记录到ORF。在有SRF的患者中，随访期间BCVA的平均变化根据SRF的存在（0.07 logMAR）或不存在（-0.125 logMAR）有显著差异（p = 0.019）。
在OCT特征中，SRF是ODP-M的不良预后因素。大多数ODP-M患者在3年的随访中视力改善或稳定。因此，对于视力尚可且无SRF的患者，即使其OCT表现显著，也可考虑进行观察。
