Osterlind A
Int J Cancer. 1987 Aug 15;40(2):161-4. doi: 10.1002/ijc.2910400206.
All records of ocular malignant melanoma notified to the Danish Cancer Registry between 1943 and 1982 were re-coded, and 1,624 out of 1,650 cases were verified and included in this investigation. The annual number of incident cases increased from about 30 to 50, but the age-standardized incidence rate remained stable at 0.75 per 100,000 in males and 0.60 in females. There was no predilection for one or the other eye in either sex. About 80% of the tumours were located in the choroid, 10% in the ciliary body and iris, 5% in the conjunctiva, and 5% in "multiple regions". The histopathology of the tumours was: epithelioid cell type in 12%, spindle-cell type in 36%, and mixed-cell type in 51%. The stable incidence rates of ocular malignant melanomas were in marked contrast to the 5- and 6-fold increase observed for cutaneous melanomas during the same time period. Possible differences in risk factors are discussed. Similarities and differences between the present data and results from other countries are highlighted.
对1943年至1982年间向丹麦癌症登记处报告的所有眼部恶性黑色素瘤记录进行了重新编码，在1650例病例中，有1624例得到核实并纳入本研究。每年的新发病例数从约30例增加到50例，但年龄标准化发病率保持稳定，男性为每10万人0.75例，女性为每10万人0.60例。两性中任何一只眼睛都没有偏好。约80%的肿瘤位于脉络膜，10%位于睫状体和虹膜，5%位于结膜，5%位于“多个区域”。肿瘤的组织病理学类型为：上皮样细胞型占12%，梭形细胞型占36%，混合细胞型占51%。眼部恶性黑色素瘤的稳定发病率与同期皮肤黑色素瘤观察到的5至6倍的增长形成鲜明对比。讨论了危险因素的可能差异。强调了本数据与其他国家结果之间的异同。
