Clinical Nutrition Unit, Catalan Institute of Oncology, L'Hospitalet de Llobregat, Spain
Bellvitge Institute for Biomedical Research, Barcelona, Spain.
BMJ Support Palliat Care. 2024 Jan 8;13(e3):e851-e854. doi: 10.1136/spcare-2022-003895.
Approximately 20% of established malignant bowel obstruction (MBO) patients do not respond to pharmacological treatment. In these cases, venting percutaneous radiologic gastrostomy (VPRG) may be useful. Existing evidence is based on retrospective studies with methodological limitations. The purpose of this study is to describe safety and effectiveness for symptom control after VPRG placement in a prospective cohort of MBO patients.
Complications of VPRG placement, symptom control, destination on discharge and survival were analysed.
Twenty-one patients were included, 13 (61.9%) of whom were women. Mean age was 62.7 years (36-85). Local pain (n=8, 38.1%) and peristomal leakage (n=4, 19%) were the most frequent minor complications. No major complications occurred. Nausea and vomiting were relieved in most patients (n=20, 95.2%) after VPRG, and small quantities of liquid diet were introduced to these patients. Median time to death after VPRG was 13 days (IQR 8.6-17.4). Thirteen patients (61.9%) were discharged, with seven of them (33.3%) returning home.
When pharmacological treatment fails, the use of VPRG in MBO patients may be feasible, safe and effective.
约 20%的已确诊恶性肠梗阻(MBO)患者对药物治疗无反应。在这些情况下,经皮放射胃造口术(VPRG)可能有用。现有证据基于具有方法学局限性的回顾性研究。本研究的目的是描述 VPRG 放置后在 MBO 患者前瞻性队列中对症状控制的安全性和有效性。
分析 VPRG 放置的并发症、症状控制、出院时的去向和生存率。
共纳入 21 例患者,其中 13 例(61.9%)为女性。平均年龄为 62.7 岁(36-85 岁)。局部疼痛(n=8,38.1%)和造口周围渗漏(n=4,19%)是最常见的轻微并发症。无重大并发症发生。VPRG 后,大多数患者(n=20,95.2%)的恶心和呕吐得到缓解,并为这些患者引入了少量液体饮食。VPRG 后死亡的中位数时间为 13 天(IQR 8.6-17.4)。13 例患者(61.9%)出院,其中 7 例(33.3%)回家。
当药物治疗失败时,VPRG 在 MBO 患者中的应用可能是可行、安全且有效的。