Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, Trondheim, Norway.
Department of Clinical and Molecular Medicine, Norwegian University of Science and Technology, Trondheim, Norway.
Health Qual Life Outcomes. 2022 Sep 14;20(1):136. doi: 10.1186/s12955-022-02044-3.
Preterm birth with very low birth weight (VLBW, birth weight < 1500 g) is associated with health problems later in life. How VLBW individuals perceive their physical and mental health-related quality of life (HRQoL) is important to understand their putative burden of disease. Previous studies have shown mixed results, and longitudinal studies into adulthood have been requested. This study aimed to investigate differences in HRQoL between preterm VLBW and term born individuals at 32 years of age, and to study changes in HRQoL from 20 to 32 years.
In a geographically based longitudinal study, 45 VLBW and 68 term born control participants completed the Short Form 36 Health Survey (SF-36) at 32 years of age. Data from three previous timepoints was also available (20, 23 and 28 years of age). The SF-36 yields eight domain scores as well as a physical and a mental component summary. Between-group differences in these variables were investigated. We also performed subgroup analyses excluding individuals with disabilities, i.e., cerebral palsy and/or low estimated intelligence quotient.
At 32 years of age, the physical component summary was 5.1 points lower (95% confidence interval (CI): 8.6 to 1.6), and the mental component summary 4.1 points lower (95% CI: 8.4 to - 0.3) in the VLBW group compared with the control group. For both physical and mental component summaries there was an overall decline in HRQoL from 20 to 32 years of age in the VLBW group. When we excluded individuals with disabilities (n = 10), group differences in domain scores at 32 years were reduced, but physical functioning, bodily pain, general health, and role-emotional scores remained lower in the VLBW subgroup without disabilities compared with the control group.
We found that VLBW individuals reported lower HRQoL than term born controls at 32 years of age, and that HRQoL declined in the VLBW group from 20 to 32 years of age. This was in part, but not exclusively explained by VLBW individuals with disabilities.
极低出生体重儿（VLBW，出生体重＜1500 克）与生命后期的健康问题有关。了解极低出生体重儿（VLBW）个体对其身心健康相关生活质量（HRQoL）的感知，对于了解他们潜在的疾病负担非常重要。先前的研究结果存在差异，因此需要进行到成年期的纵向研究。本研究旨在调查 32 岁时 VLBW 早产儿与足月出生个体之间 HRQoL 的差异，并研究 20 至 32 岁之间 HRQoL 的变化。
在一项基于地理的纵向研究中，45 名 VLBW 和 68 名足月出生的对照组参与者在 32 岁时完成了简短表格 36 健康调查（SF-36）。还可获得之前三个时间点的数据（20、23 和 28 岁）。SF-36 产生八个领域评分以及身体和精神成分综合评分。研究了这些变量的组间差异。我们还进行了亚组分析，排除了有残疾的个体，即脑瘫和/或低估计智商。
在 32 岁时，与对照组相比，VLBW 组的身体成分综合评分低 5.1 分（95%置信区间（CI）：8.6 至 1.6），精神成分综合评分低 4.1 分（95%CI：8.4 至-0.3）。从 20 岁到 32 岁，VLBW 组的 HRQoL 总体呈下降趋势。当我们排除有残疾的个体（n=10）时，32 岁时的组间差异在亚组中减少，但无残疾的 VLBW 亚组的身体功能、身体疼痛、一般健康和角色情感评分仍低于对照组。
我们发现，VLBW 个体在 32 岁时报告的 HRQoL 低于足月出生的对照组，并且从 20 岁到 32 岁，VLBW 组的 HRQoL 下降。这在一定程度上，但并非完全由有残疾的 VLBW 个体解释。
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