García-López M T, González-Muñiz R, Herranz R, Molinero M T, Del Rio J
Int J Pept Protein Res. 1987 May;29(5):613-20.
The syntheses of dipeptide derivatives of the general formula X-Trp(Nps)-OR (R = H or Me; X = Lys, Gly, Ala, Leu, Ser, Glu, His, Arg, Orn, Dpr, Gpr and Har) are described. The analgesic activities of Gpr- and Har-containing dipeptides have been evaluated and, in the light of these results, the influence of the side chain length of the basic amino acid on the analgesic effect is studied.
描述了通式为X-Trp(Nps)-OR（R = H或Me；X = Lys、Gly、Ala、Leu、Ser、Glu、His、Arg、Orn、Dpr、Gpr和Har）的二肽衍生物的合成。已评估了含Gpr和Har的二肽的镇痛活性，并根据这些结果研究了碱性氨基酸侧链长度对镇痛效果的影响。
