Yinon U, Podell M, Achiron A, Weiser Z
Int J Neurosci. 1987 Mar;33(1-2):85-91. doi: 10.3109/00207458708985931.
The callosal transfer of information to the visual cortex following its unilateral deafferentation from its geniculate input was studied in both hemispheres. Deafferentation was performed in adult cats by sectioning the optic tract. Action potentials of single cortical cells and visual evoked potentials were recorded from area 17-18 boundary in acute and chronic operated cats. In the deafferented hemisphere, cortical cells were usually visually inactive. However, some recovery of function took place in this hemisphere in the chronic cats, as expressed by the increase in the proportion of S-cells. In the intact hemisphere diminution of responsiveness and reduction of selectivity to the stimulus orientation and direction were found. The responsiveness and selectivity level in the intact hemisphere increased with postoperative time. The ocular dominance distribution in this hemisphere was similar to that of our normal control cats. The characteristics of the visual evoked potentials were in keeping with the hemispheric dominance of the cortical cells found in the experimental cats. It was concluded that a plasticity related mechanism is involved in the recovery of callosal activation of visual cortical cells following deafferentation.
在成年猫的两个半球中，研究了视束单侧传入阻断后胼胝体向视皮层的信息传递。通过切断视束对成年猫进行传入阻断。在急性和慢性手术猫的17-18区边界记录单个皮层细胞的动作电位和视觉诱发电位。在去传入的半球中，皮层细胞通常视觉无活性。然而，在慢性猫的这个半球中发生了一些功能恢复，表现为S细胞比例增加。在完整半球中，发现对刺激方向和方位的反应性降低和选择性降低。完整半球的反应性和选择性水平随术后时间增加。该半球的眼优势分布与我们正常对照猫相似。视觉诱发电位的特征与实验猫中发现的皮层细胞半球优势一致。得出的结论是，可塑性相关机制参与了去传入后视皮层细胞胼胝体激活的恢复。
