缓释化疗联合手术切除用于复发性恶性胶质瘤瘤床间质内的短期和长期疗效

Short- and long-term efficacy of sustained-release chemotherapy in tumor bed interstitium combined with surgical resection for recurrent malignant glioma.

作者信息

Wang Longlong, Wang Zhifeng, Liang Zan, Li Guojing, Duan Shibo, Xi Yanguo

机构信息

Department of Neurosurgery, Cangzhou Central Hospital Cangzhou 061000, Hebei, China.

出版信息

Am J Transl Res. 2022 Aug 15;14(8):5669-5676. eCollection 2022.

PMID:36105035

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9452319/

Abstract

OBJECTIVE

To discuss and analyze the short- and long-term curative effect of sustained-release chemotherapy combined with surgical resection on recurrent malignant glioma.

METHODS

The clinical data of 137 patients with recurrent glioma admitted to our hospital from March 2016 to July 2018 were retrospectively analyzed. Among them, 67 patients who received local chemotherapy with cisplatin slow-release polymer after surgical resection were included in the observation group, and the other 70 patients who did not receive chemotherapy after surgical resection were regarded as the control group. The short-term therapeutic efficacy, quality of life score before and after surgery, incidence of toxic and side effects, long-term recurrence rate and survival were compared between the two groups.

RESULTS

The total remission rate of clinical treatment in observation group was remarkably higher than that in control group (). There was no statistically significant difference in quality of life score between the two groups before and after surgery (). There was no significant difference in the incidence of postoperative side effects between the two groups (). While the recurrence rates of the observation group at 12 and 24 months after surgery were significantly lower than those in the control group (). The overall postoperative survival of observation group was obviously superior to that of control group (). In patients who received sustained-release chemotherapy in tumor bed interstitium combined with surgical resection, older ones and the ones with partial surgical resection or pathological grade IV had worse long-term survival (P<0.05).

CONCLUSION

The combined treatment of sustained release chemotherapy in tumor bed interstitium and surgical resection for recurrent malignant glioma can effectively improve the clinical efficacy, reduce postoperative recurrence rate and prolong the survival time of the patients.

摘要

目的

探讨并分析缓释化疗联合手术切除对复发性恶性胶质瘤的短期及长期疗效。

方法

回顾性分析2016年3月至2018年7月我院收治的137例复发性胶质瘤患者的临床资料。其中，67例患者在手术切除后接受顺铂缓释聚合物局部化疗，纳入观察组；另外70例患者在手术切除后未接受化疗，作为对照组。比较两组的短期治疗效果、手术前后生活质量评分、毒副作用发生率、长期复发率及生存率。

结果

观察组临床治疗总缓解率显著高于对照组（）。两组手术前后生活质量评分差异无统计学意义（）。两组术后副作用发生率无显著差异（）。而观察组术后12个月和24个月的复发率显著低于对照组（）。观察组术后总体生存率明显优于对照组（）。在肿瘤床间质接受缓释化疗联合手术切除的患者中，年龄较大者以及接受部分手术切除或病理分级为IV级者长期生存率较差（P<0.05）。