Carlson K H, McLaren J W, Topper J E, Brubaker R F
Invest Ophthalmol Vis Sci. 1987 Aug;28(8):1346-52.
The relationship between intraocular pressure and the rate of aqueous humor formation was studied in human subjects. Intraocular pressure was altered by changing the subject's gravity-dependent body position. Aqueous humor flow was measured fluorophotometrically. An average change of intraocular pressure of 2.4 +/- 1.2 mmHg and 11.2 +/- 2.7 mmHg was recorded in subjects whose body position was alternated +/- 15 degrees from horizontal and +/- 50 degrees from horizontal. No change of the rate of fluorescein clearance was observed for the milder change of position. A small change of fluorescein clearance was noted in response to the steeper change of position. Changing intraocular pressure seems not to induce compensatory changes in aqueous flow. Therefore we conclude that aqueous formation is relatively pressure-insensitive, a conclusion one would draw from clinical instances of angle-closure glaucoma or as in other systems of secretion, such as the toad bladder or the cerebrospinal fluid, where alterations in pressure do not necessarily influence flow. If there is a regulator of aqueous flow it is not responsive to the changes in intraocular pressure brought about in this study. If aqueous flow regulates intraocular pressure or compensates for changes in intraocular pressure, the signal is not small changes in pressure.
在人类受试者中研究了眼内压与房水生成速率之间的关系。通过改变受试者依赖重力的身体姿势来改变眼内压。采用荧光光度法测量房水流量。在身体姿势从水平方向±15度和±50度交替变化的受试者中，记录到眼内压平均变化分别为2.4±1.2 mmHg和11.2±2.7 mmHg。对于较轻微的姿势变化，未观察到荧光素清除率的变化。对于较剧烈的姿势变化，注意到荧光素清除率有微小变化。改变眼内压似乎不会引起房水流量的代偿性变化。因此我们得出结论，房水生成相对对压力不敏感，这一结论可从闭角型青光眼的临床实例中得出，或者如同在其他分泌系统中，如蟾蜍膀胱或脑脊液，压力变化不一定会影响流量。如果存在房水流量的调节因子，它对本研究中所引起的眼内压变化没有反应。如果房水流量调节眼内压或补偿眼内压变化，其信号不是压力的微小变化。
