NASA Glenn Research Center, Cleveland, OH, United States of America.
Wallace H. Coulter Dept of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA, United States of America.
PLoS One. 2020 Feb 6;15(2):e0226915. doi: 10.1371/journal.pone.0226915. eCollection 2020.
Many experiments have documented the response of intraocular pressure (IOP) to postural change. External forces caused by gravitational orientation change produce a dynamic response that is encountered every day during normal activities. Tilting the body at a small downward angle is also relevant to studying the effects of hypogravity (spaceflight), including ocular changes. We examined data from 36 independent datasets from 30 articles on IOP response to postural change, representing a total population of 821 subjects (≥1173 eyes) with widely varying initial and final postures. We confirmed that IOP was well predicted by a simple quantity, namely the hydrostatic pressure at the level of the eye, although the dependence was complex (nonlinear). Our results show that posturally induced IOP change can be explained by hydrostatic forcing plus an autoregulatory contribution that is dependent on hydrostatic effects. This study represents data from thousands of IOP measurements and provides insight for future studies that consider postural change in relation to ocular physiology, intraocular pressure, ocular blood flow and aqueous humor dynamics.
许多实验已经记录了眼压 (IOP) 对姿势变化的反应。由重力方向变化引起的外力会产生一种动态反应，这种反应在正常活动中每天都会遇到。身体小角度向下倾斜也与研究低重力（太空飞行）的影响有关，包括眼部变化。我们研究了 30 篇关于眼压对姿势变化反应的文章中的 36 个独立数据集的数据，这些文章代表了总共 821 名受试者（≥1173 只眼睛）的人群，他们的初始和最终姿势差异很大。我们证实，眼压可以通过一个简单的量很好地预测，即眼睛水平的静水压力，尽管这种依赖性很复杂（非线性）。我们的研究结果表明，姿势引起的眼压变化可以通过静水压力外加与静水压力效应相关的自动调节贡献来解释。这项研究代表了数千次眼压测量的数据，为未来的研究提供了参考，这些研究考虑了与眼球生理学、眼压、眼内血流和房水动力学相关的姿势变化。
