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用于修复大骨缺损的增材制造聚醚醚酮支架的力学方面

On the mechanical aspect of additive manufactured polyether-ether-ketone scaffold for repair of large bone defects.

作者信息

Naghavi Seyed Ataollah, Sun Changning, Hejazi Mahbubeh, Tamaddon Maryam, Zheng Jibao, Wang Leilei, Zhang Chenrui, Varma Swastina Nath, Li Dichen, Moazen Mehran, Wang Ling, Liu Chaozong

机构信息

Institute of Orthopaedic & Musculoskeletal Science, University College London, Royal National Orthopaedic Hospital, London, UK.

State Key Laboratory for Manufacturing Systems Engineering, School of Mechanical Engineering, Xi'an Jiaotong University, Xi'an, Shaanxi Province, China.

出版信息

Biomater Transl. 2022 Jun 28;3(2):142-151. doi: 10.12336/biomatertransl.2022.02.006. eCollection 2022.

Abstract

Polyether-ether-ketone (PEEK) is widely used in producing prosthesis and have gained great attention for repair of large bone defect in recent years with the development of additive manufacturing. This is due to its excellent biocompatibility, good heat and chemical stability and similar mechanical properties which mimics natural bone. In this study, three replicates of rectilinear scaffolds were designed for compression, tension, three-point bending and torsion test with unit cell size of 0.8 mm, a pore size of 0.4 mm, strut thickness of 0.4 mm and nominal porosity of 50%. Stress-strain graphs were developed from experimental and finite element analysis models. Experimental Young's modulus and yield strength of the scaffolds were measured from the slop of the stress-strain graph to be 395 and 19.50 MPa respectively for compression, 427 and 6.96 MPa respectively for tension, 257 and 25.30 MPa respectively for three-point bending and 231 and 12.83 MPa respectively for torsion test. The finite element model was found to be in good agreement with the experimental results. Ductile fracture of the struct subjected to tensile strain was the main failure mode of the PEEK scaffold, which stems from the low crystallinity of additive manufacturing PEEK. The mechanical properties of porous PEEK are close to those of cancellous bone and thus are expected to be used in additive manufacturing PEEK bone implants in the future, but the lower yield strength poses a design challenge.

摘要

聚醚醚酮(PEEK)广泛应用于假体生产,近年来随着增材制造的发展,其在大骨缺损修复方面备受关注。这是因为它具有优异的生物相容性、良好的热稳定性和化学稳定性以及与天然骨相似的力学性能。在本研究中,设计了三个直线型支架复制品用于压缩、拉伸、三点弯曲和扭转试验,其单胞尺寸为0.8毫米,孔径为0.4毫米,支柱厚度为0.4毫米,标称孔隙率为50%。通过实验和有限元分析模型绘制了应力-应变图。从应力-应变图的斜率测得支架的实验杨氏模量和屈服强度,压缩试验分别为395和19.50兆帕,拉伸试验分别为427和6.96兆帕,三点弯曲试验分别为257和25.30兆帕,扭转试验分别为231和12.83兆帕。发现有限元模型与实验结果吻合良好。PEEK支架的主要失效模式是受拉应变的支柱发生延性断裂,这源于增材制造PEEK的低结晶度。多孔PEEK的力学性能与松质骨相近,因此有望在未来用于增材制造PEEK骨植入物,但较低的屈服强度带来了设计挑战。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8c48/9465988/7ff8c39a951d/bt-03-02-142-g001.jpg

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