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肝移植治疗不可切除的自发性破裂肝细胞腺瘤:一种罕见的适应证

Liver Transplantation for Treatment of Unresectable Spontaneous Ruptured Hepatocellular Adenoma: A Rare Indication.

作者信息

Rocha Patrícia, Leal Nuno, Barbosa Manuel, De Resende Janine, Rodrigues Pedro

机构信息

Internal Medicine, Centro Hospitalar do Médio Ave EPE, Santo Tirso, PRT.

Internal Medicine, Centro Hospitalar de Vila Nova de Gaia/Espinho EPE, Vila Nova de Gaia, PRT.

出版信息

Cureus. 2022 Aug 8;14(8):e27788. doi: 10.7759/cureus.27788. eCollection 2022 Aug.

DOI:10.7759/cureus.27788
PMID:36106301
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9449253/
Abstract

Hepatocellular Adenomas (HA) are rare benign tumors of the liver which occur predominantly in young women. Although benign, HA may have complications such as hemorrhage and malignant transformation. So, sometimes conservative management is not enough. We report a case of a 26-year-old woman on oral contraceptives who presented with acute abdominal pain and signs of hemodynamic shock. She underwent transarterial embolization due to the presence of multiple HA with rupture and active hemorrhage. This minimally invasive treatment failed to control the disease. The patient presented a progressive increase in the size of the masses with signs of recent hemorrhage, and the HA became unresectable, so she underwent liver transplantation. Liver transplantation is rarely indicated for the treatment of HA; however, in unresectable masses, it should be considered to prevent potential rupture with hemorrhage or malignant transformation.

摘要

肝细胞腺瘤(HA)是一种罕见的肝脏良性肿瘤,主要发生于年轻女性。尽管是良性肿瘤,但HA可能会出现诸如出血和恶变等并发症。因此,有时保守治疗并不足够。我们报告一例26岁口服避孕药的女性患者,她因急性腹痛和血流动力学休克体征前来就诊。由于存在多个破裂并伴有活动性出血的HA,她接受了经动脉栓塞治疗。这种微创治疗未能控制病情。患者肿块大小逐渐增大且有近期出血迹象,HA变得无法切除,于是她接受了肝移植。肝移植很少用于治疗HA;然而,对于无法切除的肿块,应考虑进行肝移植以预防潜在的破裂出血或恶变。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eaba/9449253/ba59d0ad3f8d/cureus-0014-00000027788-i03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eaba/9449253/92c2944e5847/cureus-0014-00000027788-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eaba/9449253/149f5c34a6fd/cureus-0014-00000027788-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eaba/9449253/ba59d0ad3f8d/cureus-0014-00000027788-i03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eaba/9449253/92c2944e5847/cureus-0014-00000027788-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eaba/9449253/149f5c34a6fd/cureus-0014-00000027788-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eaba/9449253/ba59d0ad3f8d/cureus-0014-00000027788-i03.jpg

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Liver Transplantation for Treatment of Unresectable Spontaneous Ruptured Hepatocellular Adenoma: A Rare Indication.肝移植治疗不可切除的自发性破裂肝细胞腺瘤:一种罕见的适应证
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本文引用的文献

1
Liver Transplantation for Hepatic Adenoma: A UNOS Database Analysis and Systematic Review of the Literature.肝腺瘤的肝移植:一项器官共享联合网络数据库分析及文献系统综述
Transplant Direct. 2022 Jan 5;8(2):e1264. doi: 10.1097/TXD.0000000000001264. eCollection 2022 Feb.
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Hepatic adenoma rupture following portal vein embolization.门静脉栓塞术后肝腺瘤破裂
Radiol Case Rep. 2020 Apr 5;15(6):664-667. doi: 10.1016/j.radcr.2020.03.002. eCollection 2020 Jun.
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Hepatocellular adenoma: An unsolved diagnostic enigma.肝细胞腺瘤:一个尚未解决的诊断难题。
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Massive hepatic adenoma response to bland embolization: A case study.巨大肝腺瘤对单纯栓塞的反应:病例研究
Radiol Case Rep. 2018 Oct 11;14(1):48-51. doi: 10.1016/j.radcr.2018.09.016. eCollection 2019 Jan.
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Spontaneous Rupture of a Hepatic Adenoma: Diagnostic Nuances and the Necessity of Followup.肝腺瘤自发性破裂:诊断细微差别及随访的必要性
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