Department of Chemistry, Tokyo Institute of Technology, 2-12-1, O-okayama, Meguro-ku, Tokyo 152-8551, Japan.
Org Biomol Chem. 2022 Sep 28;20(37):7419-7423. doi: 10.1039/d2ob01416e.
We describe the synthesis of a dimerization-ready flavan derivative the Pummerer/Friedel-Crafts cascade. This method allowed facile access to oligomeric proanthocyanidin natural products. The total synthesis of procyanidin B4 was achieved by this strategy.
我们描述了一种二聚化准备好的黄烷衍生物的合成，即 Pummerer/Friedel-Crafts 级联反应。该方法可方便地获得低聚原花青素天然产物。通过该策略实现了原花青素 B4 的全合成。
