Borger J H, Keijser A H
Int J Radiat Oncol Biol Phys. 1987 Aug;13(8):1173-7. doi: 10.1016/0360-3016(87)90191-x.
Fifty-eight patients conservatively treated for T1 breast cancers are analyzed for cosmetic outcome; 17 had concomitant adjuvant combination chemotherapy (cyclophosphamide, adriamycin, 5 fluorouracil). The results are evaluated by clinical criteria and a quantitative measurement by use of light field projection at 33 months median follow-up. Surgery consisted of lumpectomy and axillary dissection; radiotherapy was given to the breast only except for additional internal mammary irradiation in central and medial lesions. (50 Gy whole breast, 64 Gy electron/photon boost). Questionnaires are used for inquiry on patient experience: 88% of the patients experienced a good to excellent cosmetic outcome. According to the panel only 64% show a good to excellent cosmesis. Panel-scores on asymmetry are compared with quantitative measurements. More esophagitis and probably a higher degree of fibrosis in the boost area is found in the chemotherapy group. No differences in cosmetic outcome, complication rates, and patient experiences are seen. Results are compared with published data.
对58例接受T1期乳腺癌保守治疗的患者的美容效果进行分析；其中17例同时接受了辅助联合化疗（环磷酰胺、阿霉素、5-氟尿嘧啶）。在中位随访33个月时，通过临床标准和使用光场投影进行定量测量来评估结果。手术包括肿块切除术和腋窝清扫术；除中央和内侧病变需额外进行内乳照射外，仅对乳房进行放疗。（全乳50 Gy，电子/光子加量64 Gy）。通过问卷调查患者的体验：88%的患者美容效果为良好至优秀。根据专家小组的评估，只有64%的患者美容效果为良好至优秀。将专家小组关于不对称性的评分与定量测量结果进行比较。化疗组在加量区域发现更多的食管炎，可能还有更高程度的纤维化。在美容效果、并发症发生率和患者体验方面未发现差异。将结果与已发表的数据进行比较。
