Department of Pediatrics, Division of Pediatric Rheumatology, Gazi University Faculty of Medicine, Ankara, Turkey.
Mod Rheumatol. 2023 Aug 25;33(5):1016-1020. doi: 10.1093/mr/roac111.
Immunoglobulin (Ig) A vasculitis (IgAV), is the most common vasculitis of childhood, is a leucocytoclastic vasculitis that affects small vessels of the skin, gastrointestinal (GI) tract, joints, and kidneys. Scrotal involvement is relatively rare. In this study, we aimed to reveal the clinical and laboratory characteristics of patients with scrotal involvement in IgAV and its relationship with other clinical features of the disease.
A total number of 301 male patients with a diagnosis of IgAV between January 2005 and 2022 were retrospectively analysed. The patients were divided into two groups as with and without scrotal involvement. The clinical and laboratory characteristics of the groups were compared.
Scrotal involvement was detected in 16.3% (49) of male IgAV patients. Scrotal involvement was unilateral in 51% of patients. While single acute scrotal attack was present in 93.9% of patients, only three patients had recurrent acute scrotal involvement. In patients with scrotal involvement, the age at diagnosis was younger (p = .007), and disease recurrence was higher (p = .003). Glucocorticoid use was more common in patients with scrotal involvement (p < .001). In multivariable analysis, a statistically significant relation between scrotal involvement and age at diagnosis (odds ratio = 0.85, 95% confidence interval 0.76-0.96, p = .006) was detected.
In IgAV patients with scrotal involvement, the age at diagnosis is lower, steroid use is more common, and recurrent disease is more frequent.
免疫球蛋白 A 血管炎（IgAV）是儿童中最常见的血管炎，是一种影响皮肤、胃肠道（GI）道、关节和肾脏小血管的白细胞碎裂性血管炎。阴囊受累相对少见。在本研究中，我们旨在揭示 IgAV 阴囊受累患者的临床和实验室特征及其与疾病其他临床特征的关系。
回顾性分析了 2005 年 1 月至 2022 年间诊断为 IgAV 的 301 名男性患者。将患者分为有阴囊受累和无阴囊受累两组。比较两组的临床和实验室特征。
16.3%（49）名男性 IgAV 患者出现阴囊受累。51%的患者阴囊受累为单侧。虽然 93.9%的患者存在单次急性阴囊发作，但仅有 3 名患者出现复发性急性阴囊受累。在有阴囊受累的患者中，诊断时的年龄较小（p=0.007），且疾病复发率较高（p=0.003）。阴囊受累患者更常使用糖皮质激素（p<0.001）。多变量分析显示，阴囊受累与诊断时年龄之间存在统计学显著关系（优势比=0.85，95%置信区间 0.76-0.96，p=0.006）。
在 IgAV 阴囊受累患者中，诊断时的年龄较低，更常使用类固醇，且疾病复发更为频繁。
