Biotechnology/Renorbio Postgraduate Program, Universidade Federal do Espírito Santo, Vitória, ES, Brazil.
Biotechnology/Renorbio Postgraduate Program, Universidade Federal do Espírito Santo, Vitória, ES, Brazil.
Life Sci. 2022 Nov 15;309:120940. doi: 10.1016/j.lfs.2022.120940. Epub 2022 Sep 12.
the present study aimed to investigate how glucose and insulin levels may be associated with changes in NR3C1 gene methylation levels in adults.
375 volunteers users of the Brazilian Public Unified Health System (SUS) were recruited to assess socioeconomic status, lifestyle, anthropometric data, blood glucose and serum cortisol levels, insulin resistance, and NR3C1 gene methylation assessment. Factors associated with glucose levels and insulin resistance were investigated using multivariate analysis GLzM at 5% significance (p<0.05).
our results verified that glucose levels and insulin resistance were directly related to NR3C1 gene methylation and age, while not being overweight and obese and no tobacco consumption were indirectly related to glucose levels and insulin resistance.
habits and lifestyle may influence NR3C1 gene regulation, revealing the complexity of environmental impacts on NR3C1 methylation. Furthermore, associated risk factors must be taken into account in epigenetic studies as they directly interfere with blood glucose levels and insulin resistance.
本研究旨在探讨葡萄糖和胰岛素水平如何与成年人 NR3C1 基因甲基化水平的变化相关。
招募了 375 名巴西公共统一医疗系统（SUS）的志愿者，以评估社会经济地位、生活方式、人体测量数据、血糖和血清皮质醇水平、胰岛素抵抗以及 NR3C1 基因甲基化评估。使用多元分析 GLzM 在 5%的显著性水平（p<0.05）探讨与血糖水平和胰岛素抵抗相关的因素。
我们的结果证实，血糖水平和胰岛素抵抗与 NR3C1 基因甲基化和年龄直接相关，而不过度肥胖和不吸烟与血糖水平和胰岛素抵抗间接相关。
习惯和生活方式可能会影响 NR3C1 基因的调控，揭示了环境对 NR3C1 甲基化影响的复杂性。此外，在表观遗传学研究中必须考虑相关的风险因素，因为它们直接干扰血糖水平和胰岛素抵抗。
