Volino-Souza Mônica, de Oliveira Gustavo Vieira, Conte-Junior Carlos Adam, Alvares Thiago Silveira
Nutrition and Exercise Metabolism Research Group, Multidisciplinary Center UFRJ-Macaé, Federal University of Rio de Janeiro, Macaé, RJ, Brazil.
Postgraduate Program in Food Science, Chemistry Institute, Federal University of Rio de Janeiro, Rio de Janeiro, RJ, Brazil.
Eur J Clin Nutr. 2023 Jan;77(1):71-74. doi: 10.1038/s41430-022-01200-8. Epub 2022 Sep 15.
BACKGROUND/OBJECTIVES: Watermelon rind (usually discarded by consumers) presents a high L-citrulline content. Given that Lcitrulline is involved in nitric oxide (NO) synthesis, a crucial molecule that regulates vascular function, this study aimed to evaluate the effect of microencapsulated watermelon rind (MWR) on endothelial function and tissue oxygen saturation (StO) assessed by flow-mediated dilation (FMD) and near-infrared spectroscopy, respectively. Plasma L-arginine and L-citrulline were also evaluated.
SUBJECT/METHODS: Eleven participants ingested 30 g of MWR (containing 4 g of L-citrulline) and a placebo. Before and 30, 60, 90, and 120 min after ingestion, StO parameters were assessed, whereas FMD and plasma amino acids were analyzed 60 and 120 min after ingestion.
The FMD improved 60 min after MWR without changes in StO parameters. Absolute plasma L-citrulline and relative change from baseline in plasma L-arginine increased 60 min after MWR ingestion.
A single dose of microencapsulated watermelon rind containing 4 g of L-citrulline seems adequate to improve FMD response, but not StO parameters in healthy adults. (NCT04781595).
背景/目的：西瓜皮（通常被消费者丢弃）含有高含量的L-瓜氨酸。鉴于L-瓜氨酸参与一氧化氮（NO）的合成，而一氧化氮是调节血管功能的关键分子，本研究旨在评估微囊化西瓜皮（MWR）对内皮功能和组织氧饱和度（StO）的影响，分别通过血流介导的血管舒张（FMD）和近红外光谱进行评估。还评估了血浆L-精氨酸和L-瓜氨酸。
受试者/方法：11名参与者摄入30克MWR（含4克L-瓜氨酸）和安慰剂。在摄入前以及摄入后30、60、90和120分钟评估StO参数，而在摄入后60和120分钟分析FMD和血浆氨基酸。
摄入MWR后60分钟FMD改善，而StO参数无变化。摄入MWR后60分钟，血浆L-瓜氨酸绝对值和血浆L-精氨酸相对于基线的变化增加。
单剂量含4克L-瓜氨酸的微囊化西瓜皮似乎足以改善健康成年人的FMD反应，但不能改善StO参数。（NCT04781595）
