微囊化西瓜（西瓜属）果皮对年轻成年人血流介导的血管舒张和组织氧饱和度的影响。

Effect of microencapsulated watermelon (Citrullus Lanatus) rind on flow-mediated dilation and tissue oxygen saturation of young adults.

作者信息

Volino-Souza Mônica, de Oliveira Gustavo Vieira, Conte-Junior Carlos Adam, Alvares Thiago Silveira

机构信息

Nutrition and Exercise Metabolism Research Group, Multidisciplinary Center UFRJ-Macaé, Federal University of Rio de Janeiro, Macaé, RJ, Brazil.

Postgraduate Program in Food Science, Chemistry Institute, Federal University of Rio de Janeiro, Rio de Janeiro, RJ, Brazil.

出版信息

Eur J Clin Nutr. 2023 Jan;77(1):71-74. doi: 10.1038/s41430-022-01200-8. Epub 2022 Sep 15.

DOI:10.1038/s41430-022-01200-8

PMID:36109652

Abstract

BACKGROUND/OBJECTIVES: Watermelon rind (usually discarded by consumers) presents a high L-citrulline content. Given that Lcitrulline is involved in nitric oxide (NO) synthesis, a crucial molecule that regulates vascular function, this study aimed to evaluate the effect of microencapsulated watermelon rind (MWR) on endothelial function and tissue oxygen saturation (StO) assessed by flow-mediated dilation (FMD) and near-infrared spectroscopy, respectively. Plasma L-arginine and L-citrulline were also evaluated.

SUBJECT/METHODS: Eleven participants ingested 30 g of MWR (containing 4 g of L-citrulline) and a placebo. Before and 30, 60, 90, and 120 min after ingestion, StO parameters were assessed, whereas FMD and plasma amino acids were analyzed 60 and 120 min after ingestion.

RESULTS

The FMD improved 60 min after MWR without changes in StO parameters. Absolute plasma L-citrulline and relative change from baseline in plasma L-arginine increased 60 min after MWR ingestion.

CONCLUSION

A single dose of microencapsulated watermelon rind containing 4 g of L-citrulline seems adequate to improve FMD response, but not StO parameters in healthy adults. (NCT04781595).

摘要

背景/目的：西瓜皮（通常被消费者丢弃）含有高含量的L-瓜氨酸。鉴于L-瓜氨酸参与一氧化氮（NO）的合成，而一氧化氮是调节血管功能的关键分子，本研究旨在评估微囊化西瓜皮（MWR）对内皮功能和组织氧饱和度（StO）的影响，分别通过血流介导的血管舒张（FMD）和近红外光谱进行评估。还评估了血浆L-精氨酸和L-瓜氨酸。

受试者/方法：11名参与者摄入30克MWR（含4克L-瓜氨酸）和安慰剂。在摄入前以及摄入后30、60、90和120分钟评估StO参数，而在摄入后60和120分钟分析FMD和血浆氨基酸。