Das Rashmi, Rout Rashmi Ranjan, Tiwari Rahul V C, Tiwari Heena Dixit, Ravuri Preetham, Kommuri Sirisha, Varma Praveen Kumar
Department of Obstetrics and Gynaecology, Veer Surendra Sai Institute of Medical Science and Research, Burla, Sambalpur, Odisha, India.
Executive MHA Student, IIHMR University, Jaipur, Rajasthan, India.
J Pharm Bioallied Sci. 2022 Jul;14(Suppl 1):S193-S195. doi: 10.4103/jpbs.jpbs_90_22. Epub 2022 Jul 13.
One of the hormones that are crucial in safe pregnancy is the Progesterone. Its defect may cause bleeding and abortion. Hence, in this study, we evaluated two different drug modalities of progesterone for their efficacy.
We piloted a prospective observational study among 100 pregnant women in their first trimester. They were divided to two equal groups to receive oral dydrogesterone and vaginal progesterone. The clinical and the demographic data with detailed history were taken and noted. The patients were followed up till the pervaginal bleeding stopped and till second trimester end. The comparisons were made between the groups using Chi square test deliberating < 0.05 as significant.
The age, BMI, and the progesterone levels were comparable between the groups. No significant difference between the groups was seen for the adverse reactions and for the continuation of pregnancy till 24 weeks. However, there was a significant variation in the cessation of the pervaginal bleeding, with lower time for the oral dydrogesterone.
Compared to the vaginal progesterone, oral dydrogesterone performed better in preventing the pervaginal bleeding and prolonging the viability of the pregnancy till the second trimester end.
孕酮是安全妊娠中至关重要的激素之一。其缺陷可能导致出血和流产。因此，在本研究中，我们评估了两种不同剂型的孕酮药物的疗效。
我们对100名孕早期孕妇进行了一项前瞻性观察研究。她们被分为两组，分别接受口服地屈孕酮和阴道用孕酮。记录临床和人口统计学数据以及详细病史。对患者进行随访，直至阴道出血停止以及孕中期结束。使用卡方检验对两组进行比较，以P<0.05为有统计学意义。
两组之间的年龄、体重指数和孕酮水平具有可比性。两组在不良反应和妊娠持续至24周方面未见显著差异。然而，在阴道出血停止方面存在显著差异，口服地屈孕酮组所需时间更短。
与阴道用孕酮相比，口服地屈孕酮在预防阴道出血和延长妊娠至孕中期结束方面表现更佳。
