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黏膜下注射地塞米松用于下颌第三磨牙手术术后疼痛及水肿控制

Sub-mucosal Dexamethasone for Post-operative Pain and Oedema Control in Lower Third Molar Surgery.

作者信息

Virkar Yogiraj B, Chawla Jitendra, Changmai Arindom, Kumar Krishna, Abhishek Kumar, Jawaid Moazzam

机构信息

Department of Dentistry, Dr. Vithalrao Vikhe Patil Foundation's Medical College and Hospital, Ahmednagar, Maharashtra, India.

Department of Dentistry, Oral and Maxillofacial Surgery, All India Institute of Medical Sciences, Manglagiri, Andhra Pradesh, India.

出版信息

J Pharm Bioallied Sci. 2022 Jul;14(Suppl 1):S816-S819. doi: 10.4103/jpbs.jpbs_8_22. Epub 2022 Jul 13.

Abstract

BACKGROUND

Surgical excision of the problematic mandibular third molars causes substantial tissue damage and an inflammatory response. Discomfort and edema are common postoperative signs and symptoms caused by the latter. To find out whether dexamethasone may help with the edema and pain that come along with the surgical removal of impacted mandibular third molars, researchers have performed clinical studies.

METHODS

Twenty individuals with bilaterally affected mandibular third molars who were scheduled for extraction participated in a prospective trial. At two separate sessions, teeth were raised and cut after buccal ostectomy. Since the surgical operation on the left foot, both patients were administered a mixture of 4 mg dexamethasone submucosal injection and antibiotics for 3 days. On the 1, 3, and 7 postoperative days, edema and pain were assessed.

RESULTS

At the 1, 3, and 7 postoperative days, there was a clinically meaningful decrease in the level of edema and discomfort in both arms.

CONCLUSIONS

The current report offers empirical proof that administering a 4 mg dexamethasone submucosal injection during surgery greatly reduced post-surgical edema and discomfort.

摘要

背景

下颌第三磨牙手术切除会造成大量组织损伤及炎症反应。不适和水肿是由后者引起的常见术后体征和症状。为了确定地塞米松是否有助于减轻下颌阻生第三磨牙拔除术后的水肿和疼痛,研究人员进行了临床研究。

方法

20例双侧下颌第三磨牙需拔除的患者参与了一项前瞻性试验。在两个不同的时间段,颊侧骨切开术后将牙齿抬起并切断。自左脚手术操作后,两名患者均接受了4毫克地塞米松黏膜下注射和抗生素联合治疗3天。在术后第1、3和7天评估水肿和疼痛情况。

结果

术后第1、3和7天,双臂的水肿程度和不适均有临床上有意义的减轻。

结论

本报告提供了经验证据,表明手术期间给予4毫克地塞米松黏膜下注射可显著减轻术后水肿和不适。

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