番茄红素、硒和维生素E在口腔白斑治疗中的效用评估。
Assessment of Utility of Lycopene, Selenium, and Vitamin E in Management of Oral Leukoplakia.
作者信息
Manas Abhigyan, Venkateswararao C H, Vaid Shivali, Dhakray Khanna Vidhi, Muhaseena M, Alvi Sadaf
机构信息
Department of Dentistry, UP University of Medical Sciences, Saifai, Utter Pradesh, India.
Department of Oral and Maxillofacial Surgery, Department of Dentistry, Nimra Institute of Medical Sciences, Jupudi, Vijayawada, Andra Pradesh, India.
出版信息
J Pharm Bioallied Sci. 2022 Jul;14(Suppl 1):S233-S235. doi: 10.4103/jpbs.jpbs_63_22. Epub 2022 Jul 13.
OBJECTIVES
To assess the utility of lycopene, selenium, and vitamin E in the management of leukoplakia.
MATERIALS AND METHODS
In this cross-sectional observational prospective study, 52 patients of oral leukoplakia were divided into 2 groups. Group I patients were prescribed 6 mg of lycopene, 400 I.U. of vitamin E, and 200 μg of selenium twice a day. Group II patients were prescribed a placebo capsule. The clinical improvement was recorded in both groups.
RESULTS
The mean pretreatment size of lesion in group I was 9.24 cm and in group II was 8.52 cm. Post treatment size was 1.52 cm in group I and 6.28 cm in group II. There was a significant reduction in the size of lesion in group I compared to group II ( < 0.05).
CONCLUSION
The treatment with a combination of lycopene, selenium, and vitamin E is useful and effective in managing the cases of oral leukoplakia.
目的
评估番茄红素、硒和维生素E在口腔白斑治疗中的效用。
材料与方法
在这项横断面观察性前瞻性研究中，52例口腔白斑患者被分为两组。第一组患者每天两次服用6毫克番茄红素、400国际单位维生素E和200微克硒。第二组患者服用安慰剂胶囊。记录两组的临床改善情况。
结果
第一组病变的平均治疗前大小为9.24厘米，第二组为8.52厘米。治疗后，第一组的大小为1.52厘米，第二组为6.28厘米。与第二组相比，第一组的病变大小有显著减小（<0.05）。
结论
番茄红素、硒和维生素E联合治疗对口腔白斑病例有效。
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