State Key Laboratory of Organic-Inorganic Composites, Beijing Key Laboratory of Bioprocess, Beijing University of Chemical Technology, Beijing 100029, China.
Bioconjug Chem. 2022 Oct 19;33(10):1934-1943. doi: 10.1021/acs.bioconjchem.2c00402. Epub 2022 Sep 16.
Gold nanoparticles (Au NPs) used as photosensitizers for photothermal therapy (PTT) have attracted extensive attention. However, limited tissue penetration of light seriously hinders the practical application, causing Au NPs to be combined with multiple theranostic agents to improve the treatment effect. Herein, we fabricate one potent gold nanostars (GNS) that can unify the dual nanozyme activities and photothermal property, achieving effective synergistic cascade catalytic and photothermal therapy. Notably, GNS is prepared by a green and facile one-step synthesis method using biodegradable poly(γ-glutamic acid) as a medium. The single GNS exhibits inherent dual nanozyme activities, glucose oxidase- and peroxidase-like activities, which not only convert glucose of tumor tissue into hydrogen peroxide (HO) but also catalyze HO to produce the amount of toxic hydroxyl radicals (•OH), leading to an amplified cascade catalytic therapy. Moreover, the cascade catalytic activity of GNS is enhanced 1.4-fold in the photothermal effect. Finally, the GNS can achieve photoacoustic imaging-guided efficient synergistic cascade catalytic and photothermal therapy with a high antitumor rate of 97.0%. This simple but multifunctional GNS could provide a new strategy facilitating the practical treatment application of single Au NPs.
金纳米星（GNS）作为光热治疗（PTT）的光敏剂引起了广泛关注。然而，有限的组织透光性严重阻碍了其实际应用，导致金纳米星与多种治疗剂结合以提高治疗效果。在此，我们构建了一种有效的金纳米星（GNS），它可以统一双纳米酶活性和光热特性，实现有效的协同级联催化和光热治疗。值得注意的是，GNS 是通过使用可生物降解的聚（γ-谷氨酸）作为介质的绿色简便的一步合成方法制备的。单个 GNS 表现出固有双纳米酶活性，即葡萄糖氧化酶和过氧化物酶样活性，不仅将肿瘤组织中的葡萄糖转化为过氧化氢（HO），而且还催化 HO 产生大量毒性羟基自由基（•OH），从而导致放大的级联催化治疗。此外，GNS 的级联催化活性在光热效应下增强了 1.4 倍。最后，GNS 可以实现光声成像引导的高效协同级联催化和光热治疗，肿瘤抑制率高达 97.0%。这种简单但多功能的 GNS 为实现单金纳米星的实际治疗应用提供了一种新策略。
