Fischbach R
Arzneimittelforschung. 1979;29(2):352-5.
Maprotiline was administered initially i.v. and then p.o. to 15 adult depressive in-patients daily for three weeks in various dosages. Serum concentrations were monitored in an attempt to find a correlation to clinical response. The steady-state serum concentration attained is independent of the dosage administered. The results suggest that patients who maintain a high serum concentration will show a better therapeutic response to the drug. In 11 out of 14 patients evaluated after three weeks of daily maprotiline therapy the clinical response could be described as excellent or very good. The drug was well tolerated when given by either route.
对15名成年抑郁住院患者初始静脉注射随后口服不同剂量的麦普替林，为期三周，每日给药。监测血清浓度以试图找出其与临床反应的相关性。达到的稳态血清浓度与给药剂量无关。结果表明，维持高血清浓度的患者对该药物将表现出更好的治疗反应。在每日麦普替林治疗三周后评估的14名患者中，有11名患者的临床反应可描述为极佳或非常好。该药物通过任何一种途径给药时耐受性良好。
