Doutre M S, Beylot C, Cardinaud F, Barberis C, Baudet J, Choussat N, Georges J M
J Chir (Paris). 1987 May;124(5):319-22.
The typical lesion of pyoderma gangrenosum is a rapidly extending necrotic ulceration, often associated with a system affection, inflammatory colitis, hematologic affections, rheumatic disorders. In about 30% of cases it develops on the site of a sometimes minimal injury. In the two cases reported one developed in the region of a graft after excision of a basal cell epithelioma, the other in a peritoneal drainage scar after colon resection. In patients with pyoderma gangrenosum, initial discussion must involve possible causes of the cutaneous necrosis, but in the cases reported the clinical appearance and rapid progression of the lesion, and negative results of serial bacteriologic and mycologic examinations were in favor of this diagnosis. An accurate diagnosis is essential since general corticotherapy is usually necessary.
坏疽性脓皮病的典型损害是迅速扩展的坏死性溃疡，常伴有系统性疾病，如炎症性肠病、血液系统疾病、风湿性疾病。约30%的病例在有时轻微损伤的部位发生。在报告的两例中，一例发生在基底细胞上皮瘤切除术后移植部位，另一例发生在结肠切除术后的腹腔引流瘢痕处。对于坏疽性脓皮病患者，初始讨论必须涉及皮肤坏死的可能原因，但在报告的病例中，病变的临床表现和快速进展以及系列细菌学和真菌学检查的阴性结果支持这一诊断。准确的诊断至关重要，因为通常需要全身皮质激素治疗。
