Department of Otolaryngology-Head and Neck Surgery, Shanghai Key Clinical Disciplines of Otolaryngology, Eye and ENT Hospital of Fudan University, 83 Fenyang Road, Xuhui District, Shanghai 200031, People's Republic of China.
J Int Med Res. 2022 Sep;50(9):3000605221122497. doi: 10.1177/03000605221122497.
Neurogenic tumors located in the larynx are extremely rare. Among them, schwannoma is a benign encapsulated tumor originating from Schwann cells, which form nerve fiber sheaths in the peripheral nervous system. We herein report a case of a schwannoma arising from a rare subsite of the larynx and review the literature on laryngeal schwannoma. The case involved a woman with a 1-month history of globus pharyngeus and dysphagia without dysphonia. Rigid laryngoscopy and magnetic resonance imaging showed a large submucosal bulge toward the medial wall of the right pyriform fossa, pushing the right false and true vocal cords and aryepiglottic fold inward. A transcervical approach was used to completely excise the tumor without incisional biopsy or preliminary tracheotomy. Histology confirmed a benign schwannoma originating from the right paraglottic space, which was extremely rare. During follow-up, no evidence of recurrence or a residual mass was found. The transcervical approach is a useful and less invasive treatment for laryngeal schwannoma located in the paraglottic space.
喉内神经源性肿瘤极为罕见。其中,神经鞘瘤是一种良性包膜肿瘤,起源于外周神经系统中的施万细胞,形成神经纤维鞘。本文报告了一例罕见喉内部位的神经鞘瘤,并对喉神经鞘瘤的文献进行了回顾。该病例为一名女性,有 1 个月的咽部异物感和吞咽困难,无声音嘶哑。硬性喉镜和磁共振成像显示右侧梨状窝内侧壁有一大型黏膜下隆起,将右侧假声带和会厌皱襞向内推。采用经颈入路完整切除肿瘤,未行切开活检或初步气管切开术。组织学证实为起源于右侧声门下区的良性神经鞘瘤,极为罕见。随访期间,未发现复发或残留肿块的证据。经颈入路是治疗位于声门下区的喉神经鞘瘤的一种有效且侵袭性较小的治疗方法。