Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA; The University of Texas MD Anderson UTHealth Graduate School of Biomedical Sciences, Houston, TX, USA.
Cell Chem Biol. 2022 Sep 15;29(9):1363-1365. doi: 10.1016/j.chembiol.2022.08.002.
ACSL4 is generally considered to be universally required for ferroptosis, a form of cell death induced by phospholipid peroxidation. In this issue of Cell Chemical Biology, Magtanong et al. (2022) report the surprising finding that ACSL4 is only required for ferroptosis in certain circumstances, raising interesting questions about the regulation of this cell death pathway.
ACSL4 通常被认为是铁死亡所必需的，铁死亡是一种由磷脂过氧化引起的细胞死亡形式。在本期《细胞化学生物学》中，Magtanong 等人（2022 年）报告了一个令人惊讶的发现，即 ACSL4 仅在某些情况下才是铁死亡所必需的，这引发了关于这条细胞死亡途径调控的有趣问题。
