Department of Chemistry, Duke University, Durham, NC, USA.
Department of Molecular Genetics and Microbiology, Duke University School of Medicine, Durham, NC, USA.
Cell Chem Biol. 2022 Sep 15;29(9):1365-1367. doi: 10.1016/j.chembiol.2022.08.005.
In this issue of Cell Chemical Biology, Vijayan and colleagues identify host factors integral for Plasmodium liver-stage infection using a whole-genome CRISPR-Cas9 knockout screen. Their efforts reveal that liver-stage parasites redistribute host microtubules to the parasite membrane in a process dependent on the host Golgi.
在本期《细胞化学生物学》中，Vijayan 及其同事利用全基因组 CRISPR-Cas9 敲除筛选，鉴定了疟原虫肝脏阶段感染所必需的宿主因子。他们的研究揭示了肝脏阶段寄生虫将宿主微管重分配到寄生虫膜的过程，该过程依赖于宿主的高尔基体。
