Baynes R D, Bothwell T H, Flax H, McDonald T P, Atkinson P, Chetty N, Bezwoda W R, Mendelow B V
J Clin Pathol. 1987 Jun;40(6):676-9. doi: 10.1136/jcp.40.6.676.
The incidence of reactive thrombocytosis in active pulmonary tuberculosis was studied in 122 patients. Thrombocytosis was common, platelet counts often exceeding 1 X 10(12)/1. A significant inverse correlation was noted between the mean platelet volume and the platelet count (r = -0.54, p less than 0.0001). Interval estimation suggested that this relation was non-linear. Further studies were done in a small group of six patients. Platelet survival was considerably shortened, the platelets aggregated excessively in vitro, serum concentrations of thrombopoiesis stimulating activity were raised, and serotonin uptake and release were within normal limits. The degree of thrombocytosis correlated significantly with the degree of inflammation measured by the erythrocyte sedimentation rate (r = 0.40, p less than 0.003) and serum C-reactive protein concentration (r = 0.35, p less than 0.008).
对122例活动性肺结核患者反应性血小板增多症的发病率进行了研究。血小板增多症很常见，血小板计数常超过1×10¹²/L。平均血小板体积与血小板计数之间存在显著负相关（r = -0.54，p＜0.0001）。区间估计表明这种关系是非线性的。对一小群6例患者进行了进一步研究。血小板生存期明显缩短，血小板在体外过度聚集，血小板生成刺激活性的血清浓度升高，5-羟色胺摄取和释放均在正常范围内。血小板增多症的程度与通过红细胞沉降率测量的炎症程度显著相关（r = 0.40，p＜0.003）以及血清C反应蛋白浓度（r = 0.35，p＜0.008）。
