Zhu Sipin, Xiang Chuan, Charlesworth Oscar, Bennett Samuel, Zhang Sijuan, Zhou Maio, Kujan Omar, Xu Jiake
Department of Orthopaedics, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, China.
Molecular Lab, School of Biomedical Sciences, University of Western Australia, Perth, Western Australia, Australia.
Front Physiol. 2022 Sep 2;13:1003931. doi: 10.3389/fphys.2022.1003931. eCollection 2022.
Junctional epithelium (JE) is a vital epithelial component which forms an attachment to the tooth surface at the gingival sulcus by the adhesion of protein complexes from its basal layer. Disruption of the JE is associated with the development of gingivitis, periodontal disease, and alveolar bone loss. Odontogenic ameloblast-associated (ODAM) is comprised of a signal peptide and an ODAM protein with 12 putative glycosylation sites. It is expressed during odontogenesis by maturation stage ameloblasts and is incorporated into the enamel matrix during the formation of outer and surface layer enamel. ODAM, as a secreted protein which is accumulated at the interface between basal lamina and enamel, mediates the adhesion of the JE to the tooth surface; and is involved with extracellular signalling of WNT and ARHGEF5-RhoA, as well as intracellular signalling of BMP-2-BMPR-IB-ODAM. ODAM is also found to be highly expressed in salivary glands and appears to have implications for the regulation of formation, repair, and regeneration of the JE. Bioinformatics and research data have identified the anti-cancer properties of ODAM, indicating its potential both as a prognostic biomarker and therapeutic target. Understanding the biology of ODAM will help to design therapeutic strategies for periodontal and dental disorders.
结合上皮（JE）是一种重要的上皮成分，它通过其基底层蛋白质复合物的黏附在牙龈沟处与牙面形成附着。结合上皮的破坏与牙龈炎、牙周病和牙槽骨丧失的发生有关。牙源性成釉细胞相关蛋白（ODAM）由一个信号肽和一个具有12个假定糖基化位点的ODAM蛋白组成。它在牙胚发育过程中由成熟阶段的成釉细胞表达，并在釉质外层和表层形成过程中整合到釉基质中。ODAM作为一种分泌蛋白，积聚在基膜与釉质之间的界面处，介导结合上皮与牙面的黏附；并参与WNT和ARHGEF5-RhoA的细胞外信号传导，以及BMP-2-BMPR-IB-ODAM的细胞内信号传导。还发现ODAM在唾液腺中高度表达，似乎对结合上皮的形成、修复和再生调节有影响。生物信息学和研究数据已经确定了ODAM的抗癌特性，表明其作为预后生物标志物和治疗靶点的潜力。了解ODAM的生物学特性将有助于设计针对牙周和牙齿疾病的治疗策略。
