Lin Jing, Ma Haoyue, Li Hang, Han Jing, Guo Tingting, Qin Zhen, Jia Liyan, Zhang Yuehui
Chinese Medicine Department, The Second Affiliated Hospital of Harbin Medical University, Harbin, China.
Heilongjiang University of Chinese Medicine, Harbin, China.
Evid Based Complement Alternat Med. 2022 Sep 7;2022:4624311. doi: 10.1155/2022/4624311. eCollection 2022.
Recently, with the development of the social economy, the incidence of infertility has increased year by year. With its complex etiology and diversified syndromes, infertility has become one of the most important diseases that plague the physical and mental health of women of childbearing age worldwide. Endometrial factors as an important part affecting female reproductive capacity, due to which induced repeated abortion and multiple uterine cavity operations occur, can destruct endometrium, failing to provide a normal implantation environment for zygote, thus resulting in infertility. Many patients failed to achieve expected results after receiving conventional treatments such as hormone therapy, assisted reproductive technology (ART), granulocyte colony-stimulating factor (G-CSF) therapy, and cell therapy, then turn to complementary and alternative medicine (CAM) therapies for help. Aiming at clarifying the effectiveness and mechanisms of CAM therapy in the treatment of infertility caused by endometrial factors, our paper systematically searched and studied present related literature on the PubMed, CNKI, and other databases, focusing on the aspects of clinical application and mechanism explorations and highlighting the therapeutic effects of Chinese herbal medicine (CHM), acupuncture, and moxibustion on such diseases. Moreover, this paper also introduces the CAM treatments of traditional Chinese medicine (TCM) retention enema, neuromuscular electrical stimulation (NMES), photobiomodulation therapy, dietary intervention, and other measures for infertility caused by endometrial factors, in order to provide a reference for subsequent basic research and clinical work.
近年来,随着社会经济的发展,不孕症的发病率逐年上升。不孕症病因复杂、证候多样,已成为困扰全球育龄女性身心健康的重要疾病之一。子宫内膜因素作为影响女性生殖能力的重要部分,因反复人工流产及多次宫腔操作等导致子宫内膜受损,无法为受精卵提供正常的着床环境,从而引发不孕。许多患者在接受激素治疗、辅助生殖技术(ART)、粒细胞集落刺激因子(G-CSF)治疗及细胞治疗等传统治疗后未能取得预期效果,进而转向补充和替代医学(CAM)疗法寻求帮助。为阐明CAM疗法在治疗子宫内膜因素所致不孕症中的有效性及作用机制,本文系统检索并研究了PubMed、中国知网等数据库中目前的相关文献,重点关注临床应用及机制探索方面,突出了中药(CHM)、针灸和艾灸对这类疾病的治疗效果。此外,本文还介绍了中医保留灌肠、神经肌肉电刺激(NMES)、光生物调节疗法、饮食干预等CAM疗法对子宫内膜因素所致不孕症的治疗措施,以期为后续的基础研究和临床工作提供参考。