Rizzo Gianluca, Feraco Alessandra, Storz Maximilian Andreas, Lombardo Mauro
Independent Researcher, Via Venezuela 66, 98121 Messina, Italy.
Laboratory of Cardiovascular Endocrinology, IRCCS San Raffaele Roma, 00166 Rome, Italy.
J Nutr Sci. 2022 Mar 7;11:e17. doi: 10.1017/jns.2022.15. eCollection 2022.
Soy is a key food in human nutrition. It is widely used in eastern traditional cuisine and it has recently diffused among self-conscious and vegetarian diets. The success of soy mainly depends on versatility and supposed healthy properties of soy foods and soy components. Meanwhile, the possible influence on endocrine system, in particular by isoflavones, raised concerns among some researchers. The present paper aims to conduct a review of available data on the effect of soy, soy foods and soy components on women's fertility and related outcomes. Eleven interventional studies, eleven observational studies and one meta-analysis have been selected from the results of queries. A weak, not clinically relevant effect has been highlighted on cycle length and hormonal status. However, a suggestive positive influence has been shown among women with fertility issues and during assisted reproductive technologies. Overall, soy and soy components consumption do not seem to perturb healthy women's fertility and can have a favourable effect among subjects seeking pregnancy. However, because of the paucity of studies exploring the impact of soy intake on women's fertility, as well as the limited population sample size, the frequently incomplete specimens’ collection to investigate all cycle phases and the insufficient characterisation of participants, the evidence is suggestive and it needs further in-depth research taking into account all these aspects.
大豆是人类营养中的一种关键食物。它在东方传统烹饪中被广泛使用，最近也在注重健康的饮食和素食饮食中流行起来。大豆的成功主要取决于大豆食品和大豆成分的多功能性以及其所谓的健康特性。与此同时，大豆尤其是异黄酮对内分泌系统可能产生的影响引起了一些研究人员的关注。本文旨在对有关大豆、大豆食品和大豆成分对女性生育能力及相关结果影响的现有数据进行综述。从检索结果中选取了11项干预性研究、11项观察性研究和1项荟萃分析。研究突出显示，大豆对月经周期长度和激素状态有微弱的、与临床无关的影响。然而，在有生育问题的女性以及辅助生殖技术过程中，大豆显示出了一定的积极影响。总体而言，食用大豆和大豆成分似乎不会干扰健康女性的生育能力，对寻求怀孕的女性可能有有利影响。然而，由于探索大豆摄入量对女性生育能力影响的研究较少，以及人口样本量有限、用于研究所有月经周期阶段的标本收集常常不完整，且参与者的特征描述不充分，现有证据只是具有启发性，需要考虑到所有这些方面进行进一步深入研究。
