Breast and Thyroid Surgery Ward, The First Affiliated Hospital of Henan University, Kaifeng 475001, China.
Contrast Media Mol Imaging. 2022 Sep 5;2022:6820281. doi: 10.1155/2022/6820281. eCollection 2022.
This work aims to explore the risk factors of lung metastasis (LM) in differentiated thyroid cancer (DTC) (LM-DTC) and the effect of treatment and to detect the relationship between LM-DTC and the levels of matrix metalloproteinase-13 (MMP-13) and micro ribonucleic acid (RNA)-142 (miR-142) in peripheral blood. The data of 420 patients with DTC who are admitted from March 2020 to December 2021 are collected and divided into a non-metastasis group (non-LM group) of 400 cases and metastasis group (LM group) of 20 cases according whether the mung metastasis is found. In addition, risk factors of LM-DTC are analysed and compared. The results of multivariate logistic analysis show that age, disease course, and imaging timing are independent influencing factors of the radionuclide treatment effect. Follicular carcinoma, abnormal expressions of MMP-13, and miR-142 can increase the risk of LM-DTC. MMP-13 and miR-142 can be undertaken as auxiliary diagnostic biological indicators.
本研究旨在探讨分化型甲状腺癌（DTC）肺转移（LM）的危险因素及治疗效果，并检测外周血中基质金属蛋白酶-13（MMP-13）和微小 RNA-142（miR-142）水平与 LM-DTC 的关系。收集 2020 年 3 月至 2021 年 12 月收治的 420 例 DTC 患者的临床资料，根据是否发生远处转移分为无转移组（非 LM 组）400 例和转移组（LM 组）20 例，分析并比较 LM-DTC 的危险因素。多因素 logistic 分析结果显示，年龄、病程、影像学时机是影响核素治疗效果的独立影响因素。滤泡状癌、MMP-13 及 miR-142 异常表达可增加 LM-DTC 的发生风险，MMP-13 和 miR-142 可作为辅助诊断的生物学指标。
