Khoshdel Zahra, Tomas Shibi, Jafari Marziye
Department of Pharmacy Practice, Karnataka College of Pharmacy, Bengaluru, Karnataka, India.
Department of Clinical Pharmacy, Faculty of Pharmacy, Guilan University of Medical Science, Rasht, Iran.
J Family Med Prim Care. 2022 Jun;11(6):2393-2398. doi: 10.4103/jfmpc.jfmpc_542_21. Epub 2022 Jun 30.
The main objective of the present study is to find out the loose links between prescription of medication and its utilization in the pediatric department, especially with drugs that belong to the antiepileptic medication category.
This prospective observational study was carried out for 6 months in the Department of Pharmacy Practice, Tertiary Care Hospital, Bangalore. The study was conducted on 100 patients receiving antiepileptic medication. The patient demographics and all medically relevant information were noted in a predefined data collection form.
The study showed that the maximum number of patients receiving antiepileptic medication belongs to the age group of 2-6 years. While comparing the prevalence of ADR levetiracetam, phenytoin and clobazam were identified which are associated with ADR. The highly prescribed drug was valproic acid and carbamazepine. The ADRs documented were loss of appetite, vomiting, anemia, and Steven-Johnson syndrome. Evaluation of prescription was performed, which is a major factor in drug-related ADRs. In the discussion part, various methods of improvement in the prevention of ADRs due to prescription error have been suggested which can improve drug utilization and precaution. An economic study was done in the end to put a light on the cost-effective treatment therapy which might improve patient adherence.
It was concluded that valproic acid was a highly prescribed drug and carbamazepine was the second-most prescribed drug. It was found that majority of prescription was without a generic name and with inappropriate abbreviations.
本研究的主要目的是找出儿科药物处方与其使用之间的松散联系，特别是与抗癫痫药物类别相关的药物。
这项前瞻性观察性研究在班加罗尔三级护理医院的药学实践部进行了6个月。该研究对100名接受抗癫痫药物治疗的患者进行。患者人口统计学信息和所有医学相关信息都记录在预先定义的数据收集表中。
研究表明，接受抗癫痫药物治疗的患者中人数最多的年龄组为2至6岁。在比较不良反应发生率时，发现左乙拉西坦、苯妥英和氯巴占与不良反应有关。处方量最高的药物是丙戊酸和卡马西平。记录的不良反应有食欲不振、呕吐、贫血和史蒂文斯 - 约翰逊综合征。对处方进行了评估，这是药物相关不良反应的一个主要因素。在讨论部分，提出了各种改进方法以预防因处方错误导致的不良反应，这些方法可以提高药物使用和预防措施。最后进行了一项经济学研究，以阐明可能提高患者依从性的具有成本效益的治疗方法。
得出的结论是丙戊酸是处方量最高的药物，卡马西平是处方量第二高的药物。发现大多数处方没有通用名且缩写不当。
