Pathak Apeksha, Siddalingesha R, Prasad Kamal N, Kamal Nibha, Sinha Archana, Ghosh Ananya, Singh Bhuwan K, Kumar Pankaj, Surekha R
Rajendra Institute of Medical Sciences, Ranchi, Jharkhand, India.
J Family Med Prim Care. 2022 Jun;11(6):2483-2487. doi: 10.4103/jfmpc.jfmpc_1450_21. Epub 2022 Jun 30.
Hyperbilirubinemia is most common normal physiological phenomenon in neonates affecting almost one third of newborn.it may lead to neuro disability leading to deafness and cerebral palsy which can be prevented if detected and treated as soon as possible. Albumin is produced in seventh week of intrauterine life and it can be measured by cord blood and in this study we can establish serum albumin with neonatal hyperbilirubinemia and can be treated by phototherapy or exchange transfusion.
The study consists of 55 randomly selected eligible term neonates delivered at Rajendra Institute of Medical sciences from March 2019 to August 2020.
In this study, in term neonates, level of serum albumin in umbilical cord less than 2.8 g/dl has no correlation with occurrence significant hyperbilirubinemia, so a level <2.8 gm/dl of serum albumin in umbilical cord blood can be used as critical value indicator in triaging predict the risk of occurring of significant hyperbilirubinemia in term neonates.level >3.4 gm/dl is considered safe in neonates who are the candidates for early discharge in the absence of other risk factors.
高胆红素血症是新生儿中最常见的正常生理现象,几乎影响三分之一的新生儿。它可能导致神经功能障碍,进而引发耳聋和脑瘫,如果能尽早发现并治疗,这些情况是可以预防的。白蛋白在子宫内生活的第七周产生,可以通过脐血进行检测,在本研究中,我们可以确定血清白蛋白与新生儿高胆红素血症的关系,并且可以通过光疗或换血疗法进行治疗。
本研究包括2019年3月至2020年8月在拉金德拉医学科学研究所随机选取的55名符合条件的足月儿。
在本研究中,对于足月儿,脐带血血清白蛋白水平低于2.8 g/dl与显著高胆红素血症的发生无关,因此脐带血血清白蛋白水平<2.8 gm/dl可作为一个临界值指标,用于在分诊时预测足月儿发生显著高胆红素血症的风险。在没有其他危险因素的情况下,对于有早期出院可能的新生儿,血清白蛋白水平>3.4 gm/dl被认为是安全的。