Li Qiuyu, Wei Xuejing, Wang Yanfei, Liu Chang, Fan Boshi, Lv Cheng, Si Wenzhe, Li Min
Department of Respiratory and Critical Care Medicine, Peking University Third Hospital, Beijing, China.
Department of Pathology, Beijing Friendship Hospital, Capital Medical University, Beijing, China.
Front Oncol. 2022 Aug 24;12:916906. doi: 10.3389/fonc.2022.916906. eCollection 2022.
Mucoepidermoid carcinoma is dominant in salivary glands and rarely occurs in the lung. Primary pulmonary mucoepidermoid carcinoma is a type of non-small-cell lung cancer, but the prognostic factors in Chinese patients remain controversial. This investigation aimed to review cases of pulmonary mucoepidermoid carcinoma, analyse the prognosis of this disease.
Patients with pathologically proven pulmonary mucoepidermoid carcinoma were screened at the Department of Respiratory and Critical Care Medicine at the Peking University Third Hospital, Beijing Friendship Hospital Affiliated to Capital Medical University, and Peking University Cancer Hospital for inclusion in this retrospective study. Demographic data, including age, sex, clinical symptoms, smoking, alcohol consumption, allergies, family history, imaging findings, fibrobronchoscopy findings, surgical procedures, tumour location and pathologic stage, were collected. Telephone follow-up was conducted for all patients not lost to follow-up. The associations of sex, age, smoking, tumour differentiation, tumour size, lymph node metastasis, pathologic stage, and patient survival were retrospectively analysed. Kaplan-Meier, univariate and multivariate analysis curves were used to analyse patient prognosis and prognostic factors.
Thirty-one patients, comprising 23 males and 8 females, were enrolled in the analysis. The mean age was 60.77 ± 11.44 years. The first symptom was nonspecific, with cough being the most common (21/31, 67.77%); smokers accounted for 16 of the 31 patients, and ten patients had a history of alcohol consumption. Overall, the tumours could occur in either lobe of the lungs; tumours occurred in the right lung in 19/31 patients, and tumours occurred in the left lung in 12/31 patients. Regarding TNM stage, 10 patients had stage I (5 with stage 1a, 5 with stage 1b), 5 had stage II (1 with stage 2a, 4 with stage 2b), 3 had stage III (1 with stage 3a, 2 with stage 3b), and 13 had stage IV (10 with stage 4a, 3 with stage 4b). In our Cox univariate survival analysis of patients with pulmonary mucoepidermoid carcinoma, we found that TNM stage IV, degree of differentiation and lymph node metastasis were risk factors for pulmonary mucoepidermoid carcinoma and that degree of differentiation was an independent risk factor.
The clinical, radiographical and pathological features of pulmonary mucoepidermoid carcinoma were systemically analysed and summarized, and the degree of differentiation and lymph node metastasis, as well as prognostic factors in addition to clinical stage, were confirmed.
黏液表皮样癌在唾液腺中占主导，在肺部很少发生。原发性肺黏液表皮样癌是一种非小细胞肺癌，但中国患者的预后因素仍存在争议。本研究旨在回顾肺黏液表皮样癌病例，分析该疾病的预后。
在北京大学生命科学学院第三医院呼吸与危重症医学科、首都医科大学附属北京友谊医院和北京大学肿瘤医院筛选出经病理证实的肺黏液表皮样癌患者纳入本回顾性研究。收集人口统计学数据，包括年龄、性别、临床症状、吸烟、饮酒、过敏史、家族史、影像学检查结果、纤维支气管镜检查结果、手术方式、肿瘤位置和病理分期。对所有未失访的患者进行电话随访。回顾性分析性别、年龄、吸烟、肿瘤分化程度、肿瘤大小、淋巴结转移、病理分期与患者生存情况的相关性。采用Kaplan-Meier曲线、单因素和多因素分析曲线分析患者预后及预后因素。
31例患者纳入分析，其中男性23例，女性8例。平均年龄为60.77±11.44岁。首发症状无特异性，最常见的是咳嗽（21/31，67.77%）；31例患者中有16例吸烟，10例有饮酒史。总体而言，肿瘤可发生于两肺的任何一叶；19/31例患者肿瘤发生于右肺，12/31例患者肿瘤发生于左肺。关于TNM分期，10例患者为I期（5例为1a期，5例为1b期），5例为II期（1例为2a期，4例为2b期），3例为III期（1例为3a期，2例为3b期），13例为IV期（10例为4a期，3例为4b期）。在我们对肺黏液表皮样癌患者的Cox单因素生存分析中，我们发现TNM分期IV期、分化程度和淋巴结转移是肺黏液表皮样癌的危险因素，且分化程度是独立危险因素。
系统分析和总结了肺黏液表皮样癌的临床、影像学和病理特征，确定了分化程度和淋巴结转移以及除临床分期外的预后因素。
