Smith Paul F
Department of Pharmacology and Toxicology, School of Biomedical Sciences and Brain Health Research Centre, University of Otago, Dunedin, New Zealand.
Eisdell Moore Centre for Hearing and Balance Research, University of Auckland, Auckland, New Zealand.
Front Neurol. 2022 Sep 2;13:986302. doi: 10.3389/fneur.2022.986302. eCollection 2022.
Over the last two decades, evidence has accumulated to demonstrate that the vestibular system has extensive connections with areas of the brain related to spatial memory, such as the hippocampus, and also that it has significant interactions with areas associated with voluntary motor control, such as the striatum in the basal ganglia. In fact, these functions are far from separate and it is believed that interactions between the striatum and hippocampus are important for memory processing. The data relating to vestibular-hippocampal-striatal interactions have considerable implications for the understanding and treatment of Alzheimer's Disease and Parkinson's Disease, in addition to other neurological disorders. However, evidence is accumulating rapidly, and it is difficult to keep up with the latest developments in these and related areas. The aim of this review is to summarize and critically evaluate the relevant evidence that has been published over the last 2 years (i.e., since 2021), in order to identify emerging themes in this research area.
在过去二十年中，越来越多的证据表明，前庭系统与大脑中与空间记忆相关的区域（如海马体）有着广泛的联系，并且它还与与自主运动控制相关的区域（如基底神经节中的纹状体）存在显著的相互作用。事实上，这些功能并非相互独立，人们认为纹状体和海马体之间的相互作用对记忆处理很重要。除了其他神经系统疾病外，与前庭 - 海马体 - 纹状体相互作用相关的数据对阿尔茨海默病和帕金森病的理解与治疗具有重要意义。然而，证据积累迅速，很难跟上这些及相关领域的最新进展。本综述的目的是总结并批判性地评估过去两年（即自2021年以来）已发表的相关证据，以便确定该研究领域中出现的新主题。
