Zhou Baochang, Zhang Guoqing, Guo Wenfang, Ren Cunxia, Li Minhui
Inner Mongolia Medical University, Hohhot 010110, China.
Inner Mongolia Hospital Of Traditional Chinese Medicine, Hohhot 010110, China.
Chin Herb Med. 2021 Aug 27;14(1):130-141. doi: 10.1016/j.chmed.2021.08.004. eCollection 2022 Jan.
To systematically evaluate the clinical effect of Xiaoke Decoction in the treatment of type 2 diabetes.
Chinese databases such as CNKI, Wanfang, Weipu Chinese Biomedical Journal Database, and Chinese Medical Biological Literature Database, PubMed, Cochrane Library, Embase, and Web of Science were searched for English language literature from their inception until November 2019. A Meta-analysis was performed using RevMan 5.3 and Stata 12.0.
Thirty-eight studies were included in this study, with a total of 3757 patients. It was found that adding Xiaoke Decoction could improve total efficiency. The Xiaoke Decoction groups surpassed the western medicine groups regarding improvement in total efficiency (OR = 3.49; 95% CI: 2.78-4.39, < 0.00001). Adding Xiaoke Decoction could lower the fasting plasma glucose (FPG) level. The Xiaoke Decoction groups surpassed the western medicine groups regarding reduction in FPG levels (MD = -1.14; 95% CI: -1.36 to 0.92, < 0.00001). Adding Xiaoke Decoction could lower the 2 h postprandial blood glucose (2hPG) level. The Xiaoke Decoction groups surpassed the western medicine groups regarding reduction in 2hPG (MD = -1.40; 95% CI: -1.61 to 1.19, < 0.00001). Adding Xiaoke Decoction could lower glycated hemoglobin (HbA1c). The Xiaoke Decoction groups surpassed the western medicine groups regarding reduction in HbA1c (MD = -0.77; 95% CI: -0.95 to 0.58, < 0.00001). It was found that adding Xiaoke Decoction could lower the traditional Chinese medicine (TCM) syndrome score. The TCM syndrome scores among patients in the Xiaoke Decoction group were lower than those among patients in the control group after treatment (MD = -4.90; 95% CI: -7.22 to 2.57, < 0.0001). At the same time, we conducted a subgroup and sensitivity analysis of age and intervention duration on the heterogeneity of total efficiency, FPG, 2hPG, HbAlc, and TCM syndrome score outcome indicators. For detecting publication bias, an egger test was conducted.
Compared with western medicine alone, Xiaoke Decoction has more advantages for the treatment of type 2 diabetes with respect to total efficiency, FPG, 2hPG, HbAlc, and TCM syndrome score.
系统评价消渴汤治疗2型糖尿病的临床疗效。
检索中国知网、万方、维普中文生物医学期刊数据库、中国生物医学文献数据库等中文数据库，以及PubMed、Cochrane图书馆、Embase和Web of Science等英文数据库，检索时间从建库至2019年11月。使用RevMan 5.3和Stata 12.0进行Meta分析。
本研究共纳入38项研究，共计3757例患者。结果发现，加用消渴汤可提高总有效率。在总有效率的改善方面，消渴汤组优于西药组（OR = 3.49；95%CI：2.78 - 4.39，P < 0.00001）。加用消渴汤可降低空腹血糖（FPG）水平。在FPG水平降低方面，消渴汤组优于西药组（MD = -1.14；95%CI：-1.36至 -0.92，P < 0.00001）。加用消渴汤可降低餐后2小时血糖（2hPG）水平。在2hPG降低方面，消渴汤组优于西药组（MD = -1.40；95%CI：-1.61至 -1.19，P < 0.00001）。加用消渴汤可降低糖化血红蛋白（HbA1c）。在HbA1c降低方面，消渴汤组优于西药组（MD = -0.77；95%CI：-0.95至 -0.58，P < 0.00001）。结果发现，加用消渴汤可降低中医证候积分。治疗后，消渴汤组患者的中医证候积分低于对照组患者（MD = -4.90；95%CI：-7.22至 -2.57，P < 0.0001）。同时，我们对年龄和干预持续时间进行亚组分析和敏感性分析，以探讨其对总有效率、FPG、2hPG、HbAlc和中医证候积分结局指标异质性的影响。为检测发表偏倚，进行了Egger检验。
与单纯西药相比，消渴汤在治疗2型糖尿病的总有效率、FPG、2hPG、HbAlc和中医证候积分方面更具优势。
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