DeAsis D N, Ali M K, Soto A, Samaan N A
Cancer. 1978 Oct;42(4):2005-8. doi: 10.1002/1097-0142(197810)42:4<2005::aid-cncr2820420448>3.0.co;2-4.
A 47-year-old male with histiocytic lymphoma and no previous history of heart disease developed significant fluctuations of blood pressure, electrocardiographic evidence of myocardial ischemia, and life-threatening arrhythmia after the first dose of BACOP (bleomycin, adriamycin, cyclophosphamide, Oncovin, and prednisone) chemotherapy. The presence of pheochromocytoma was suspected, and it was demonstrated by elevated urinary metanephrines, catecholamines, and vanillylmandelic acid, and finally confirmed on autopsy. The possible role of chemotherapeutic agents in stimulating excessive catecholamine release, thus causing transient cardiac injury, is suggested.
一名47岁男性，患有组织细胞性淋巴瘤，既往无心脏病史，在接受第一剂BACOP（博来霉素、阿霉素、环磷酰胺、长春新碱和泼尼松）化疗后，出现血压显著波动、心肌缺血的心电图证据以及危及生命的心律失常。怀疑存在嗜铬细胞瘤，尿中变肾上腺素、儿茶酚胺和香草扁桃酸升高证实了这一怀疑，最终经尸检确诊。提示化疗药物可能刺激过多儿茶酚胺释放，从而导致短暂性心脏损伤。
