Bennison Sarah A, Liu Xiaonan, Toyo-Oka Kazuhito
Department of Neurobiology and Anatomy, Drexel University College of Medicine, Philadelphia, PA 19129, USA.
Department of Pharmacology and Physiology, Drexel University College of Medicine, Philadelphia, PA 19102, USA.
Cell Signal. 2022 Dec;100:110472. doi: 10.1016/j.cellsig.2022.110472. Epub 2022 Sep 16.
Protein kinases represent important signaling hubs for a variety of biological functions. Many kinases are traditionally studied for their roles in cancer cell biology, but recent advances in neuroscience research show repurposed kinase function to be important for nervous system development and function. Two members of the AMP-activated protein kinase (AMPK) related family, NUAK1 and NUAK2, have drawn attention in neuroscience due to their mutations in autism spectrum disorder (ASD), attention deficit hyperactivity disorder (ADHD), schizophrenia, and intellectual disability (ID). Furthermore, Nuak kinases have also been implicated in tauopathy and other disorders of aging. This review highlights what is known about the Nuak kinases in nervous system development and disease and explores the possibility of Nuak kinases as targets for therapeutic innovation.
蛋白激酶是多种生物学功能的重要信号枢纽。传统上，许多激酶因其在癌细胞生物学中的作用而被研究，但神经科学研究的最新进展表明，激酶功能的重新利用对神经系统的发育和功能很重要。AMP激活的蛋白激酶（AMPK）相关家族的两个成员，NUAK1和NUAK2，因其在自闭症谱系障碍（ASD）、注意力缺陷多动障碍（ADHD）、精神分裂症和智力残疾（ID）中的突变而在神经科学领域引起了关注。此外，Nuak激酶也与tau蛋白病和其他衰老相关疾病有关。本综述重点介绍了关于Nuak激酶在神经系统发育和疾病方面的已知信息，并探讨了将Nuak激酶作为治疗创新靶点的可能性。
