The Second Affiliated Hospital and School of Basic Medical Sciences of Shandong First Medical University and Shandong Academy of Medical Science, Taian, China.
School of Nursing, Shandong First Medical University and Shandong Academy of Medical Sciences, Taian, China.
Am J Clin Nutr. 2022 Nov;116(5):1208-1218. doi: 10.1093/ajcn/nqac261. Epub 2023 Feb 10.
Alcohol-induced hangover represents a significant, yet understudied, global hazard and a large socioeconomic burden.
The aim of this study was to investigate the effects of hydrogen on relieving drinking and hangover symptoms in 20 healthy volunteers.
In this pilot, randomized, double-blinded, placebo-controlled, matched, crossover interventional trial, participants were matched into pairs and randomly assigned. Study group 1 inhaled placebo air for 1 h, followed by drinking 100 mL liquor (40% alcohol) within 10 min, and then pure water. Study group 2 inhaled a mixture of hydrogen and oxygen gas for 1 h, followed by drinking 100 mL liquor within 10 min, and then hydrogen dissolved in water. On a second intervention day (crossover) ≥1 wk later, study-group subjects were switched to the opposite order. Breath alcohol concentration (BrAC), hangover severity, and cognitive scores were measured.
The BrACs within the hydrogen group were significantly lower than those within the placebo group after 30 min, 60 min, and 90 min (P< 0.05). The hydrogen group reported having fewer hangover symptoms compared with the placebo group (placebo: 77% of symptoms absent, 19.7% of mild symptoms, 2.7% of moderate symptoms, 0.7% of severe symptoms; hydrogen: 88.6% of symptoms absent, 10% of mild symptoms, 1.3% of moderate symptoms, 0% of severe symptoms; P< 0.001). Hydrogen treatment improved cognitive testing scores (P< 0.05), including attention and executive functions. Furthermore, consumption of hydrogen was negatively (β = -13.016; 95% CI: -17.726, -8.305; P< 0.001) and female sex was positively (β = 22.611; 95% CI: 16.226, 28.997; P< 0.001) correlated with increased BrACs. Likewise, the consumption of hydrogen was negatively (OR: 0.035; 95% CI: 0.007, 0.168; P< 0.001) while female sex was positively (OR: 28.838; 95% CI: 5.961, 139.506; P< 0.001) correlated with the severity of hangover symptoms.
Hydrogen decreases BrACs and relieves the symptoms of hangovers. This trial was registered at the China Clinical Trial Registry (http://www.chictr.org.cn/showproj.aspx?proj=58359) as ChiCTR2200059988.
酒精引起的宿醉是一种重要但研究不足的全球危害，也是一个巨大的社会经济负担。
本研究旨在调查氢气对 20 名健康志愿者饮酒和宿醉症状的缓解作用。
在这项初步的、随机的、双盲的、安慰剂对照、匹配的、交叉干预临床试验中，参与者被匹配成对子并随机分配。研究组 1 吸入安慰剂空气 1 小时，然后在 10 分钟内饮用 100 毫升（40%酒精）白酒，然后饮用纯水。研究组 2 吸入氢气和氧气混合物 1 小时，然后在 10 分钟内饮用 100 毫升白酒，然后饮用溶解在水中的氢气。在第二个干预日（交叉）≥1 周后，研究组受试者切换到相反的顺序。测量呼气酒精浓度（BrAC）、宿醉严重程度和认知评分。
氢气组在 30 分钟、60 分钟和 90 分钟后，BrAC 明显低于安慰剂组（P<0.05）。与安慰剂组相比，氢气组报告的宿醉症状较少（安慰剂：77%的症状不存在，19.7%的症状轻微，2.7%的症状中度，0.7%的症状严重；氢气：88.6%的症状不存在，10%的症状轻微，1.3%的症状中度，0%的症状严重；P<0.001）。氢气治疗改善了认知测试评分（P<0.05），包括注意力和执行功能。此外，饮酒量（β=-13.016；95%CI：-17.726，-8.305；P<0.001）与女性性别（β=22.611；95%CI：16.226，28.997；P<0.001）呈负相关，与 BrAC 升高有关。同样，饮酒量（OR：0.035；95%CI：0.007，0.168；P<0.001）与女性性别（OR：28.838；95%CI：5.961，139.506；P<0.001）呈负相关，与宿醉症状的严重程度有关。
氢气降低 BrAC 并缓解宿醉症状。本试验在中国临床试验注册中心（http://www.chictr.org.cn/showproj.aspx?proj=58359）注册，注册号为 ChiCTR2200059988。
