School of Biosciences, Faculty of Science and Engineering, University of Nottingham Malaysia, 43500, Selangor, Malaysia.
School of Bioscience, Faculty of Medicine, Bioscience and Nursing, MAHSA University, 42610, Selangor, Malaysia.
Chem Biodivers. 2022 Nov;19(11):e202200655. doi: 10.1002/cbdv.202200655. Epub 2022 Oct 10.
Selected traditional medicinal plants exhibit therapeutic effects in coronavirus disease (Covid-19) patients. This review aims to identify the phytochemicals from five traditional medicinal plants (Glycyrrhiza glabra, Nigella sativa, Curcuma longa, Tinospora cordifolia and Withania somnifera) with high potential in modulating the main protease (Mpro) activity and cytokine storm in Covid-19 infection. The Mpro binding affinity of 13 plant phytochemicals were in the following order: Withanoside II>withanoside IV>withaferin A>α-hederin>withanoside V>sitoindoside IX>glabridin>liquiritigenin, nigellidine>curcumin>glycyrrhizin>tinocordiside>berberine. Among these phytochemicals, glycyrrhizin, withaferin A, curcumin, nigellidine and cordifolioside A suppressed SARS-CoV-2 replication and showed stronger anti-inflammatory activities than standard Covid-19 drugs. Both preclinical and clinical evidences supported the development of plant bioactive compounds as Mpro inhibitors.
五种传统药用植物(甘草、黑种草、姜黄、三裂叶薯和睡茄)中的部分植物化学物质具有调节冠状病毒病(Covid-19)患者主要蛋白酶(Mpro)活性和细胞因子风暴的潜力。本研究旨在鉴定这些药用植物中的植物化学物质。这 13 种植物化学物质对 Mpro 的结合亲和力按以下顺序排列:醉茄内酯 II>醉茄内酯 IV>醉茄素 A>α-荷丹醇>醉茄内酯 V>薯蓣皂苷元 IX>甘草素>甘草苷>黑种草碱>姜黄素>甘草酸>锡诺索苷>小檗碱。其中,甘草酸、醉茄素 A、姜黄素、黑种草碱和薯蓣皂苷元 A 抑制 SARS-CoV-2 的复制,并显示出比标准 Covid-19 药物更强的抗炎活性。临床前和临床证据都支持将植物生物活性化合物开发为 Mpro 抑制剂。