Weesner K M, Kaplan K
J Med Primatol. 1987;16(3):185-202.
Stumptailed macaques (Macaca arctoides) were evaluated as to their suitability as an animal model for pulmonary hypertension. Animals used for this study were colony-bred. Necropsy material from 63 animals revealed 32% with severe medial thickening of pulmonary arteries. Twenty-nine stumptailed macaques underwent cardiac catheterization and M-mode echocardiography. Hemodynamic measurement including pulmonary artery pressure response to 12% oxygen exposure identified three groups of animals with elevated, normal, and intermediate pulmonary artery pressures. Stumptailed macaques with elevated pulmonary artery pressure could be distinguished from other animals by echocardiography.
对短尾猕猴（Macaca arctoides）作为肺动脉高压动物模型的适用性进行了评估。用于本研究的动物是群体饲养繁殖的。对63只动物的尸检材料显示，32%的动物肺动脉中膜严重增厚。对29只短尾猕猴进行了心导管检查和M型超声心动图检查。血流动力学测量，包括对12%氧气暴露的肺动脉压力反应，确定了三组肺动脉压力升高、正常和中等的动物。肺动脉压力升高的短尾猕猴可以通过超声心动图与其他动物区分开来。
