Lopez-Bergami Pablo
Centro de Estudios Biomédicos, Básicos, Aplicados y Desarrollo (CEBBAD), Universidad Maimónides, Hidalgo 775, 6th Floor, Lab 602, 1405, Buenos Aires, Argentina.
Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), 1425, Buenos Aires, Argentina.
Cancer Cell Int. 2022 Sep 20;22(1):288. doi: 10.1186/s12935-022-02711-x.
Receptor tyrosine kinase-like orphan receptor 2 (ROR2) is a receptor for the Wnt5a ligand that was shown to play a dual role in cancer. ROR2 was shown to either suppress or promote tumor progression in different tumor types by regulating the same biological processes (i.e. proliferation, invasion) in opposite ways. We have recently observed that ROR2 plays multiple and somewhat contradictory roles in melanoma where it impairs cell proliferation but promotes migration, EMT and chemoresistance. In the present article, ROR2 is proposed to be a major driver of "phenotype switching" in melanoma that can tilt the cellular behavior toward proliferative or invasive phenotypes. This function of ROR2 has therapeutic implications since it would provide an opportunity for targeting specific phenotypes such as invasive and drug-resistant ones by inhibiting ROR2.
受体酪氨酸激酶样孤儿受体2（ROR2）是Wnt5a配体的受体，已证明其在癌症中发挥双重作用。研究表明，ROR2通过以相反方式调节相同的生物学过程（即增殖、侵袭），在不同肿瘤类型中既可以抑制也可以促进肿瘤进展。我们最近观察到，ROR2在黑色素瘤中发挥多种且有些矛盾的作用，它会损害细胞增殖，但促进迁移、上皮-间质转化和化疗耐药性。在本文中，ROR2被认为是黑色素瘤中“表型转换”的主要驱动因素，它可以使细胞行为倾向于增殖或侵袭性表型。ROR2的这一功能具有治疗意义，因为它将为通过抑制ROR2来靶向特定表型（如侵袭性和耐药性表型）提供机会。
