Ali Shereen, Nagieb Clair Sobhy, Fayed Hala Lotfy
Department of Oral Medicine and Periodontology, Faculty of Dentistry, Cairo University, Egypt.
Department of Rheumatology & Rehabilitation, Faculty of Medicine, Cairo University, Egypt.
Spec Care Dentist. 2023 Jul-Aug;43(4):435-442. doi: 10.1111/scd.12782. Epub 2022 Sep 20.
The current study assessed the clinical characteristics of patients suffering from Behcet's disease (BD)-associated oral ulcers and investigated the effect of these oral ulcers on the oral health-related quality of life (OHRQoL).
This study included BD patients suffering from active oral ulcers, defined by the revised International Criteria for BD (ICBD) criteria. We collected BD and oral ulcers characteristics. The oral ulcer activity index and OHRQoL were measured by composite index (CI) and Oral Health Impact Profile-14 (OHIP-14), respectively.
Genital and ocular manifestations were the most frequent. Ocular manifestations were the main diagnostic manifestation. The mean age of BD diagnosis and first oral ulcer appearance were 32.15 ± 8.96 and 29.62 ± 9.04, respectively. Minor oral ulcers were more frequent; solitary or multiple. CI revealed that pain was more severe than functional disability. OHIP-14 showed that patients suffered more often from pain and difficulties in eating. Patients reported feeling tense, being irritable, doing usual job with difficulty, and having less satisfying life.
BD-associated oral ulcers lead to poor quality of life. Female gender, multiple ulcers, and buccal mucosa were associated with more severe pain and functional disability as well as poorer quality of life.
本研究评估了白塞病（BD）相关口腔溃疡患者的临床特征，并调查了这些口腔溃疡对口腔健康相关生活质量（OHRQoL）的影响。
本研究纳入了符合修订的白塞病国际标准（ICBD）中定义的活动性口腔溃疡的BD患者。我们收集了BD和口腔溃疡的特征。口腔溃疡活动指数和OHRQoL分别通过综合指数（CI）和口腔健康影响程度量表-14（OHIP-14）进行测量。
生殖器和眼部表现最为常见。眼部表现是主要的诊断表现。BD诊断和首次出现口腔溃疡的平均年龄分别为32.15±8.96岁和29.62±9.04岁。轻度口腔溃疡更为常见；可为单个或多个。CI显示疼痛比功能障碍更为严重。OHIP-14表明患者更多地遭受疼痛和进食困难。患者报告感到紧张、易怒、难以从事日常工作且生活满意度较低。
BD相关口腔溃疡导致生活质量较差。女性、多个溃疡以及颊黏膜与更严重的疼痛、功能障碍以及更差的生活质量相关。
