BF·EtO介导的α-酮酸与脂肪族酮的环化反应用于合成γ-羟基丁烯内酯和γ-亚烷基丁烯内酯。
BF·EtO-Mediated annulation of α-keto acids with aliphatic ketones for the synthesis of γ-hydroxy-butenolides and γ-alkylidene-butenolides.
作者信息
Cheng Zhenfeng, Gu Qingyun, Xie Yushan, Zhang Yanan, Zeng Xiaobao
机构信息
School of Pharmacy, Nantong University Nantong 226001 P. R. China
出版信息
RSC Adv. 2022 Aug 25;12(37):24237-24241. doi: 10.1039/d2ra04546j. eCollection 2022 Aug 22.
Abstract
Annulation reaction of α-keto acids with cyclic or acyclic aliphatic ketones is reported herein to divergently access γ-hydroxy-butenolides and γ-alkylidene-butenolides depending on the amount of BF·EtO. This protocol features good functional tolerance and ease of operation, to open a route to access butenolides an annulation and dehydration process.
摘要
本文报道了α-酮酸与环状或无环脂肪族酮的环化反应，根据BF·EtO的用量不同，可以不同地得到γ-羟基丁烯内酯和γ-亚烷基丁烯内酯。该方法具有良好的官能团耐受性和操作简便性，为通过环化和脱水过程获得丁烯内酯开辟了一条途径。
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