铱催化的α-氧代羧酸与 1,3-二烯的立体选择性[3+2]环加成反应。
Iridium-catalyzed stereoselective [3+2] annulation of α-oxocarboxylic acids with 1,3-dienes.
机构信息
Department of Chemistry, Graduate School of Science, Osaka City University, Sumiyoshi, Osaka 558-8585, Japan.
Department of Chemistry, Graduate School of Science, Kyoto University, Sakyo, Kyoto 606-8502, Japan.
出版信息
Chem Commun (Camb). 2021 Jun 15;57(48):5917-5920. doi: 10.1039/d1cc02003j.
PMID:34008643
Abstract
The stereoselective annulation of α-oxocarboxylic acids with 1,3-dienes proceeded in the presence of a hydroxoiridium catalyst to give α-hydroxy-γ-lactones in good yields with high 3,5-trans relative stereochemistry. The use of a chiral diene ligand for a cationic iridium complex enabled asymmetric annulation with high enantioselectivity.
摘要
在羟铱催化剂的存在下，α-氧代羧酸与 1,3-二烯进行立体选择性环化反应，以高收率和高 3,5-顺式相对立体化学选择性得到α-羟基-γ-内酯。手性二烯配体的使用使阳离子铱配合物能够进行高对映选择性的不对称环化反应。
Zotero 插件