ENVIRONMENTAL RESEARCH AND POLLUTION PREVENTION UNIT, UNIVERSITY OF AL-QADISIYAH, AL DIWANIYAH, IRAQ.
DEPARTMENT OF BIOMEDICAL ENGINEERING, AL-MUSTAQBAL UNIVERSITY COLLEGE, HILLA, IRAQ.
Wiad Lek. 2022;75(8 pt 2):1965-1969. doi: 10.36740/WLek202208204.
The aim: To determine the distribution of Candida spp. within different age groups and contraceptive methods in women with vulvovaginitis, as well as the susceptibility of Candida spp. to commonly used antifungals.
Materials and methods: High vaginal swabs were taken from 98 women aged 18 to 50 with vulvovaginitis who used contraceptives and attended the Women and Children Hospital in Al-Diwaniyah; after diagnosis of Candida species, the sensitivity of Candida spp. to some antifungals was studied.
Results: The results showed (43/98) women (43.87%) used IUD, (15/98) women (15.30%) used birth control pills, (7/98) women (7.14%) used an injection of contraceptive, (5/98) women (5.10%) used contraceptive suppositories, and (28/98) women (28.57%) did not use any contraceptives. Candida spp. was found in (48/83) specimens (57.831%) from women who used contraceptives and only (11/28) specimens (39.285%) from women who did not use contraceptives. Only (59/98) vaginal specimens tested positive for vaginal candidiasis, (28/59) isolates (47.457%) for C. albicans, then (16/59) isolates for C. glabrata (27.118%), (9/59) isolates (15.254%) for C. tropicalis and (6/59) isolates (10.169%) for C. krusei. Nystatin was the best treatment for all Candida spp. under study, and the MIC was 6.25, and the MFC was 50 for all antifungals and Candida species under study.
Conclusions: C. albicans was the most prevalent cause of vulvovaginal candidiasis, while C. glabrata was the most common non-albicans species in women aged 26 to 35; using an IUD was associated with an increased infection of vulvovaginal candidiasis, and nystatin was the most effective treatment.
确定阴道炎患者中不同年龄组和避孕方法中 Candida spp. 的分布情况，以及 Candida spp. 对常用抗真菌药物的敏感性。
材料和方法：从在迪瓦尼亚妇幼医院就诊并使用避孕措施的 98 名年龄在 18 至 50 岁的阴道炎女性中采集阴道高位拭子；在诊断出念珠菌属后，研究了 Candida spp. 对一些抗真菌药物的敏感性。
结果表明，（43/98）名女性（43.87%）使用宫内节育器，（15/98）名女性（15.30%）使用避孕药，（7/98）名女性（7.14%）使用避孕注射剂，（5/98）名女性（5.10%）使用避孕栓剂，（28/98）名女性（28.57%）未使用任何避孕措施。在使用避孕措施的女性中，有（48/83）份标本（57.831%）中发现了 Candida spp.，而在未使用避孕措施的女性中只有（11/28）份标本（39.285%）中发现了 Candida spp.。仅（59/98）份阴道标本检测出阴道念珠菌病阳性，（28/59）份分离株（47.457%）为 C. albicans，然后（16/59）份分离株为 C. glabrata（27.118%），（9/59）份分离株为 C. tropicalis（15.254%）和（6/59）份分离株为 C. krusei（10.169%）。所有研究的念珠菌属对制霉菌素的治疗效果最好，MIC 为 6.25，所有抗真菌药物和念珠菌属的 MFC 均为 50。
C. albicans 是引起阴道念珠菌病最常见的原因，而 C. glabrata 是 26 至 35 岁女性中最常见的非白色念珠菌属；使用宫内节育器与阴道念珠菌病感染增加有关，制霉菌素是最有效的治疗方法。
