Sakai A, Serizawa K, Watanabe M, Endo S, Suzuki T, Morishita M
Jpn J Antibiot. 1987 Mar;40(3):493-7.
Tissue distribution of rokitamycin (TMS-19-Q) was studied after oral administration of 50 mg/kg to fasted Beagle dogs. Tissue concentrations of TMS-19-Q reached their peaks at 1-2 hours after the administration. The order of tissue concentrations of TMS-19-Q was liver greater than kidney greater than spleen greater than lung greater than mesenteric lymph node greater than heart greater than tonsil greater than serum greater than prostate gland greater than uterus greater than skin. At the peak time, drug concentrations in tonsil and lung were about 1.1 and 1.4 times higher, respectively, than that in serum.
给禁食的比格犬口服50mg/kg的罗他霉素（TMS-19-Q）后，研究了其组织分布。给药后1-2小时，TMS-19-Q的组织浓度达到峰值。TMS-19-Q的组织浓度顺序为肝脏＞肾脏＞脾脏＞肺＞肠系膜淋巴结＞心脏＞扁桃体＞血清＞前列腺＞子宫＞皮肤。在峰值时刻，扁桃体和肺中的药物浓度分别比血清中的药物浓度高约1.1倍和1.4倍。
