Ogura H, Tomoda T, Hamada F, Fujieda M, Ohara Y, Araki K, Kitamura I
Jpn J Antibiot. 1987 Mar;40(3):680-4.
A new cephem antibiotic, cefuzonam (L-105, CZON) was studied for its concentrations in serum and clinical efficacy in the field of pediatrics. To examine the concentration of CZON in serum, 20 mg/kg of CZON was administered by intravenous drip infusion to a male patient of 6 years and 7 months. The half-life of the drug in serum was 0.97 hour after administration. CZON was administered to 7 cases of pediatric infections, and clinical result were "excellent" in 4, "good" in 1, "poor" in 2: the efficacy rate was 71.4% or 5 cases out of 7. As an adverse reaction, eruption was observed in 1 patient.
一种新型头孢烯类抗生素头孢唑南（L - 105，CZON）在儿科领域的血清浓度及临床疗效方面进行了研究。为检测血清中头孢唑南的浓度，对一名6岁7个月的男性患者静脉滴注20mg/kg的头孢唑南。给药后该药物在血清中的半衰期为0.97小时。对7例儿科感染患者使用了头孢唑南，临床结果为4例“优”，1例“良”，2例“差”：有效率为71.4%，即7例中有5例有效。作为不良反应，1例患者出现了皮疹。
